Transplantable hepatomas induced in strain-2 guinea pigs by diethylnitrosamine

Characterization by histology, growth, and chromosomes

Berton Zbar, Harold T. Wepsic, Herbert J. Rapp, Jacqueline Whang-Peng, Tibor Borsos

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Six hepatomas, each induced in a different strain-2 guinea pig, were studied. Four of the six tumors were different in histologic appearance, transplantability, and chromosomal constitution. Two of the six tumors (lines 1 and 8) were similar in these characteristics. During transplantation of one of the tumors (line 7 in the ascites form), a subline arose that differed from line 7 in histologic appearance, transplantability, and chromosomal constitution. This subline (7B) was biologically similar to lines 1 and 8.

Original languageEnglish
Pages (from-to)821-831
Number of pages11
JournalJournal of the National Cancer Institute
Volume43
Issue number4
DOIs
Publication statusPublished - Jan 1 1969
Externally publishedYes

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Diethylnitrosamine
Hepatocellular Carcinoma
Histology
Guinea Pigs
Chromosomes
Constitution and Bylaws
Growth
Neoplasms
Ascites
Transplantation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Transplantable hepatomas induced in strain-2 guinea pigs by diethylnitrosamine : Characterization by histology, growth, and chromosomes. / Zbar, Berton; Wepsic, Harold T.; Rapp, Herbert J.; Whang-Peng, Jacqueline; Borsos, Tibor.

In: Journal of the National Cancer Institute, Vol. 43, No. 4, 01.01.1969, p. 821-831.

Research output: Contribution to journalArticle

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