Translocation t(11;22) in esthesioneuroblastoma

Jacqueline Whang-Peng; Carl E. Freter; Turid Knutsen; J. J. Nanfro; Adi Gazdar

doi:10.1016/0165-4608(87)90043-4

Translocation t(11;22) in esthesioneuroblastoma

Jacqueline Whang-Peng, Carl E. Freter, Turid Knutsen, J. J. Nanfro, Adi Gazdar

Research output: Contribution to journal › Article › peer-review

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Abstract

Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.

Original language	English
Pages (from-to)	155-157
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(87)90043-4
Publication status	Published - Jan 1 1987
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

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AU - Knutsen, Turid

AU - Nanfro, J. J.

AU - Gazdar, Adi

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N2 - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.

AB - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.

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Translocation t(11;22) in esthesioneuroblastoma

Abstract

ASJC Scopus subject areas

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