Abstract
Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
| Original language | English |
|---|---|
| Pages (from-to) | 155-157 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
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Translocation t(11;22) in esthesioneuroblastoma. / Whang-Peng, Jacqueline; Freter, Carl E.; Knutsen, Turid; Nanfro, J. J.; Gazdar, Adi.
In: Cancer Genetics and Cytogenetics, Vol. 29, No. 1, 01.01.1987, p. 155-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translocation t(11;22) in esthesioneuroblastoma
AU - Whang-Peng, Jacqueline
AU - Freter, Carl E.
AU - Knutsen, Turid
AU - Nanfro, J. J.
AU - Gazdar, Adi
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
AB - Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.
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U2 - 10.1016/0165-4608(87)90043-4
DO - 10.1016/0165-4608(87)90043-4
M3 - Article
VL - 29
SP - 155
EP - 157
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -