Translocation of c-sis protooncogene in peripheral neuroepithelioma

Carol J. Thiele, Jacqueline Whang-Peng, Chien Song Kao-Shan, James Miser, Mark A. Israel

Research output: Contribution to journalArticle

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Abstract

Molecular genetic analysis of the c-sis protooncogene was performed on two neuroepithelioma cell lines carrying a t(11;22)(q24;q12). The c-sis protooncogene was found by in situ hybridization to be translocated from its germline position on chromosome #22 to the derivative chromosome #11 in each cell line. However, it was not rearranged or amplified in either cell line examined. In addition, we did not detect c-sis transcripts in Northern blots of poly (A)+ RNA. This is similar to results found in Ewing's sarcoma, which carries a cytogenetically indistinguishable translocation from neuroepithelioma.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalCancer Genetics and Cytogenetics
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 1987
Externally publishedYes

Fingerprint

Peripheral Primitive Neuroectodermal Tumors
Cell Line
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 11
Ewing's Sarcoma
Northern Blotting
In Situ Hybridization
Molecular Biology
Messenger RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Translocation of c-sis protooncogene in peripheral neuroepithelioma. / Thiele, Carol J.; Whang-Peng, Jacqueline; Kao-Shan, Chien Song; Miser, James; Israel, Mark A.

In: Cancer Genetics and Cytogenetics, Vol. 24, No. 1, 01.01.1987, p. 119-128.

Research output: Contribution to journalArticle

Thiele, Carol J. ; Whang-Peng, Jacqueline ; Kao-Shan, Chien Song ; Miser, James ; Israel, Mark A. / Translocation of c-sis protooncogene in peripheral neuroepithelioma. In: Cancer Genetics and Cytogenetics. 1987 ; Vol. 24, No. 1. pp. 119-128.
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