Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

Chi Mei Wang, Shan Jen Li, Chi Hao Wu, Chien Ming Hu, Hui Wen Cheng, Jung Su Chang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Hepatic Stellate Cells
Ferritins
Cytokines
Serum
Liver Cirrhosis
Horses
Liver Diseases
Interleukin-6
Chronic Disease
Inflammation
Neoplasms

Keywords

  • Endoplasmic reticulum stress
  • Grp78
  • Hepatic stellate cells
  • Liver fibrosis
  • Serum ferritin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

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abstract = "Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p",
keywords = "Endoplasmic reticulum stress, Grp78, Hepatic stellate cells, Liver fibrosis, Serum ferritin",
author = "Wang, {Chi Mei} and Li, {Shan Jen} and Wu, {Chi Hao} and Hu, {Chien Ming} and Cheng, {Hui Wen} and Chang, {Jung Su}",
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T1 - Transient knock down of Grp78 reveals roles in serum ferritin mediated pro-inflammatory cytokine secretion in rat primary activated hepatic stellate cells

AU - Wang, Chi Mei

AU - Li, Shan Jen

AU - Wu, Chi Hao

AU - Hu, Chien Ming

AU - Cheng, Hui Wen

AU - Chang, Jung Su

PY - 2014

Y1 - 2014

N2 - Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

AB - Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine IL1β, IL6 and TNFα secretion in rat activated HSCs (all p

KW - Endoplasmic reticulum stress

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KW - Liver fibrosis

KW - Serum ferritin

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