Transient expression of A-type K+ channel α subunits Kv4.2 and Kv4.3 in rat spinal neurons during development

Hsin Yi Huang, Chien Wei Liao, Pei Hsuan Chen, Meei Ling Tsaur

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A-type K+ currents (IAs) have been detected from the ventral horn neurons in rat spinal cord during embryonic day (E) 14 to postnatal day (P) 8 but not in adulthood. It is not known which types of neurons and which A-type K+ channel α subunits express the IAs and what the possible function might be. Here, we examined the expression of two A-type K+ channel α subunits, Kv4.2 and Kv4.3, in rat spinal cord at various developmental stages by immunohistochemistry. We found a transient expression of Kv4.2 in somatic motoneurons during E13.5-P8 with a peak around E17.5, which coincides temporally with the natural selection of motoneurons. Transient expression of Kv4.2 and Kv4.3 was also observed in the intermediate gray (IG) interneurons. During E19.5-P14, some IG interneurons express Kv4.2, some express Kv4.3 and a subset co-express Kv4.2 and Kv4.3. Peak expression of Kv4.2 and Kv4.3 in the IG interneurons was detected around P1, which coincides temporally with the developmental selection of IG interneurons. In contrast to the IA-expressing subunits Kv4.2 and Kv4.3, a delayed-rectifier K+ channel α subunit Kv1.6 is persistently expressed in somatic motoneurons and IG interneurons. Together, these data support the hypothesis that expression of IAs may protect I A-expressing somatic motoneurons, and possibly also IG interneurons, from naturally occurring cell death during developmental selection.

Original languageEnglish
Pages (from-to)1142-1150
Number of pages9
JournalEuropean Journal of Neuroscience
Volume23
Issue number5
DOIs
Publication statusPublished - Mar 2006
Externally publishedYes

Keywords

  • Development
  • Intermediate gray interneurons
  • Rat
  • Somatic motoneurons
  • Visceral motoneurons

ASJC Scopus subject areas

  • Neuroscience(all)

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