Transdermal delivery of selegiline from alginate-Pluronic composite thermogels

Chih Chieh Chen, Chia Lang Fang, Saleh A. Al-Suwayeh, Yann Lii Leu, Jia You Fang

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The present work was carried out to design a practical, controlled-release transdermal system for selegiline using thermosensitive hydrogels. The copolymers of alginate and Pluronic F127 (PF127) were used to design thermogels by either physical blending (A + P) or chemical grafting (AP). The thermogels were characterized in terms of the sol-gel temperature, scanning electron microscopy (SEM), degradation ratio, and skin permeation behavior. The chemical grafting of alginate to PF127 could delay the sol-gel temperature from 24.1 to 30.4 °C, which is near the temperature of the skin surface. The gelling temperature of the physical mixture of alginate and PF127 (A + P) did not significantly differ. The porosity of the A + P structure was greater compared to that of the AP structure. AP thermogels were regularly degraded, with 60% of the gel matrix remaining after a 48-h incubation. PF127 and A + P hydrogels showed almost no degradation. The results of skin permeation across porcine skin and nude mouse skin suggested that the thermogels could produce sustained selegiline release, with AP showing the most-sustained permeation. AP hydrogels exhibited linear permeation properties for the transdermal delivery of selegiline. Inter-subject variations in skin permeation were reduced by incorporation of the thermogel. Such a thermosensitive hydrogel can be advantageous as a topical therapeutic formulation for selegiline.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume415
Issue number1-2
DOIs
Publication statusPublished - Aug 30 2011

Fingerprint

UCON 50-HB-5100
Selegiline
Poloxamer
Hydrogels
Skin
Gels
Polymethyl Methacrylate
Temperature
Skin Temperature
Hydrogel
Porosity
Nude Mice
Electron Scanning Microscopy
Swine
alginic acid

Keywords

  • Alginate
  • Pluronic F127
  • Selegiline
  • Thermogel
  • Transdermal delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Transdermal delivery of selegiline from alginate-Pluronic composite thermogels. / Chen, Chih Chieh; Fang, Chia Lang; Al-Suwayeh, Saleh A.; Leu, Yann Lii; Fang, Jia You.

In: International Journal of Pharmaceutics, Vol. 415, No. 1-2, 30.08.2011, p. 119-128.

Research output: Contribution to journalArticle

Chen, Chih Chieh ; Fang, Chia Lang ; Al-Suwayeh, Saleh A. ; Leu, Yann Lii ; Fang, Jia You. / Transdermal delivery of selegiline from alginate-Pluronic composite thermogels. In: International Journal of Pharmaceutics. 2011 ; Vol. 415, No. 1-2. pp. 119-128.
@article{80b1d85729f6487583210947bde946f8,
title = "Transdermal delivery of selegiline from alginate-Pluronic composite thermogels",
abstract = "The present work was carried out to design a practical, controlled-release transdermal system for selegiline using thermosensitive hydrogels. The copolymers of alginate and Pluronic F127 (PF127) were used to design thermogels by either physical blending (A + P) or chemical grafting (AP). The thermogels were characterized in terms of the sol-gel temperature, scanning electron microscopy (SEM), degradation ratio, and skin permeation behavior. The chemical grafting of alginate to PF127 could delay the sol-gel temperature from 24.1 to 30.4 °C, which is near the temperature of the skin surface. The gelling temperature of the physical mixture of alginate and PF127 (A + P) did not significantly differ. The porosity of the A + P structure was greater compared to that of the AP structure. AP thermogels were regularly degraded, with 60{\%} of the gel matrix remaining after a 48-h incubation. PF127 and A + P hydrogels showed almost no degradation. The results of skin permeation across porcine skin and nude mouse skin suggested that the thermogels could produce sustained selegiline release, with AP showing the most-sustained permeation. AP hydrogels exhibited linear permeation properties for the transdermal delivery of selegiline. Inter-subject variations in skin permeation were reduced by incorporation of the thermogel. Such a thermosensitive hydrogel can be advantageous as a topical therapeutic formulation for selegiline.",
keywords = "Alginate, Pluronic F127, Selegiline, Thermogel, Transdermal delivery",
author = "Chen, {Chih Chieh} and Fang, {Chia Lang} and Al-Suwayeh, {Saleh A.} and Leu, {Yann Lii} and Fang, {Jia You}",
year = "2011",
month = "8",
day = "30",
doi = "10.1016/j.ijpharm.2011.05.060",
language = "English",
volume = "415",
pages = "119--128",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Transdermal delivery of selegiline from alginate-Pluronic composite thermogels

AU - Chen, Chih Chieh

AU - Fang, Chia Lang

AU - Al-Suwayeh, Saleh A.

AU - Leu, Yann Lii

AU - Fang, Jia You

PY - 2011/8/30

Y1 - 2011/8/30

N2 - The present work was carried out to design a practical, controlled-release transdermal system for selegiline using thermosensitive hydrogels. The copolymers of alginate and Pluronic F127 (PF127) were used to design thermogels by either physical blending (A + P) or chemical grafting (AP). The thermogels were characterized in terms of the sol-gel temperature, scanning electron microscopy (SEM), degradation ratio, and skin permeation behavior. The chemical grafting of alginate to PF127 could delay the sol-gel temperature from 24.1 to 30.4 °C, which is near the temperature of the skin surface. The gelling temperature of the physical mixture of alginate and PF127 (A + P) did not significantly differ. The porosity of the A + P structure was greater compared to that of the AP structure. AP thermogels were regularly degraded, with 60% of the gel matrix remaining after a 48-h incubation. PF127 and A + P hydrogels showed almost no degradation. The results of skin permeation across porcine skin and nude mouse skin suggested that the thermogels could produce sustained selegiline release, with AP showing the most-sustained permeation. AP hydrogels exhibited linear permeation properties for the transdermal delivery of selegiline. Inter-subject variations in skin permeation were reduced by incorporation of the thermogel. Such a thermosensitive hydrogel can be advantageous as a topical therapeutic formulation for selegiline.

AB - The present work was carried out to design a practical, controlled-release transdermal system for selegiline using thermosensitive hydrogels. The copolymers of alginate and Pluronic F127 (PF127) were used to design thermogels by either physical blending (A + P) or chemical grafting (AP). The thermogels were characterized in terms of the sol-gel temperature, scanning electron microscopy (SEM), degradation ratio, and skin permeation behavior. The chemical grafting of alginate to PF127 could delay the sol-gel temperature from 24.1 to 30.4 °C, which is near the temperature of the skin surface. The gelling temperature of the physical mixture of alginate and PF127 (A + P) did not significantly differ. The porosity of the A + P structure was greater compared to that of the AP structure. AP thermogels were regularly degraded, with 60% of the gel matrix remaining after a 48-h incubation. PF127 and A + P hydrogels showed almost no degradation. The results of skin permeation across porcine skin and nude mouse skin suggested that the thermogels could produce sustained selegiline release, with AP showing the most-sustained permeation. AP hydrogels exhibited linear permeation properties for the transdermal delivery of selegiline. Inter-subject variations in skin permeation were reduced by incorporation of the thermogel. Such a thermosensitive hydrogel can be advantageous as a topical therapeutic formulation for selegiline.

KW - Alginate

KW - Pluronic F127

KW - Selegiline

KW - Thermogel

KW - Transdermal delivery

UR - http://www.scopus.com/inward/record.url?scp=79960162474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960162474&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2011.05.060

DO - 10.1016/j.ijpharm.2011.05.060

M3 - Article

VL - 415

SP - 119

EP - 128

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -