Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis

Jia Y. Fang, Kuo Chun Sung, O. Y P Hu, Hsiang Y. Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The objective of this study was to evaluate the in vitro transdermal permeation of nalbuphine hydrochloride (CAS 23277-43-2) (NA) and nalpuphine pivalate (NAP), a novel prodrug of NA, from different hydrogel formulations under passive diffusion as well as iontophoresis. Various concentrations of polymers, including polyvinylpyrrolidone (PVP) and hydroxypropyl cellulose (HPC) were used in the hydrogel formulations. The passive permeation rate of NA was affected by the polymer concentrations, which can be attributed to different viscosities of the hydrated formulations; whereas the passive permeation rate of NAP was not influenced by the various polymer concentrations. Iontophoresis significantly increased the permeation rates of NA and NAP from various hydrogel formulations through skin; the enhancement ratios were higher for NA in all the formulations studied. The iontophoretic permeation rates of NA were slightly decreased by the incorporation of polymers; however, the transdermal flux and membrane potential were independent of polymer concentrations for both NA and NAP, demonstrating that the polymer concentrations in the hydrogel formulations did not have significant effects on the iontophoretic permeation of NA and NAP.

Original languageEnglish
Pages (from-to)408-413
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Volume51
Issue number5
Publication statusPublished - 2001

Fingerprint

Nalbuphine
Iontophoresis
Hydrogels
Permeation
Polymers
Hydrogel
Povidone
Prodrugs
Viscosity
Membrane Potentials
nalbuphine pivalate
Skin
Fluxes
Membranes

Keywords

  • CAS 23277-43-2
  • Iontophoresis
  • Nalbuphine
  • Nalbuphine pivalate
  • Transdermal drug delivery, diffusion

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis. / Fang, Jia Y.; Sung, Kuo Chun; Hu, O. Y P; Chen, Hsiang Y.

In: Arzneimittel-Forschung/Drug Research, Vol. 51, No. 5, 2001, p. 408-413.

Research output: Contribution to journalArticle

@article{6ffba6218a7647d4b2c6cd948fd3579b,
title = "Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis",
abstract = "The objective of this study was to evaluate the in vitro transdermal permeation of nalbuphine hydrochloride (CAS 23277-43-2) (NA) and nalpuphine pivalate (NAP), a novel prodrug of NA, from different hydrogel formulations under passive diffusion as well as iontophoresis. Various concentrations of polymers, including polyvinylpyrrolidone (PVP) and hydroxypropyl cellulose (HPC) were used in the hydrogel formulations. The passive permeation rate of NA was affected by the polymer concentrations, which can be attributed to different viscosities of the hydrated formulations; whereas the passive permeation rate of NAP was not influenced by the various polymer concentrations. Iontophoresis significantly increased the permeation rates of NA and NAP from various hydrogel formulations through skin; the enhancement ratios were higher for NA in all the formulations studied. The iontophoretic permeation rates of NA were slightly decreased by the incorporation of polymers; however, the transdermal flux and membrane potential were independent of polymer concentrations for both NA and NAP, demonstrating that the polymer concentrations in the hydrogel formulations did not have significant effects on the iontophoretic permeation of NA and NAP.",
keywords = "CAS 23277-43-2, Iontophoresis, Nalbuphine, Nalbuphine pivalate, Transdermal drug delivery, diffusion",
author = "Fang, {Jia Y.} and Sung, {Kuo Chun} and Hu, {O. Y P} and Chen, {Hsiang Y.}",
year = "2001",
language = "English",
volume = "51",
pages = "408--413",
journal = "Drug Research",
issn = "2194-9379",
publisher = "Thieme",
number = "5",

}

TY - JOUR

T1 - Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis

AU - Fang, Jia Y.

AU - Sung, Kuo Chun

AU - Hu, O. Y P

AU - Chen, Hsiang Y.

PY - 2001

Y1 - 2001

N2 - The objective of this study was to evaluate the in vitro transdermal permeation of nalbuphine hydrochloride (CAS 23277-43-2) (NA) and nalpuphine pivalate (NAP), a novel prodrug of NA, from different hydrogel formulations under passive diffusion as well as iontophoresis. Various concentrations of polymers, including polyvinylpyrrolidone (PVP) and hydroxypropyl cellulose (HPC) were used in the hydrogel formulations. The passive permeation rate of NA was affected by the polymer concentrations, which can be attributed to different viscosities of the hydrated formulations; whereas the passive permeation rate of NAP was not influenced by the various polymer concentrations. Iontophoresis significantly increased the permeation rates of NA and NAP from various hydrogel formulations through skin; the enhancement ratios were higher for NA in all the formulations studied. The iontophoretic permeation rates of NA were slightly decreased by the incorporation of polymers; however, the transdermal flux and membrane potential were independent of polymer concentrations for both NA and NAP, demonstrating that the polymer concentrations in the hydrogel formulations did not have significant effects on the iontophoretic permeation of NA and NAP.

AB - The objective of this study was to evaluate the in vitro transdermal permeation of nalbuphine hydrochloride (CAS 23277-43-2) (NA) and nalpuphine pivalate (NAP), a novel prodrug of NA, from different hydrogel formulations under passive diffusion as well as iontophoresis. Various concentrations of polymers, including polyvinylpyrrolidone (PVP) and hydroxypropyl cellulose (HPC) were used in the hydrogel formulations. The passive permeation rate of NA was affected by the polymer concentrations, which can be attributed to different viscosities of the hydrated formulations; whereas the passive permeation rate of NAP was not influenced by the various polymer concentrations. Iontophoresis significantly increased the permeation rates of NA and NAP from various hydrogel formulations through skin; the enhancement ratios were higher for NA in all the formulations studied. The iontophoretic permeation rates of NA were slightly decreased by the incorporation of polymers; however, the transdermal flux and membrane potential were independent of polymer concentrations for both NA and NAP, demonstrating that the polymer concentrations in the hydrogel formulations did not have significant effects on the iontophoretic permeation of NA and NAP.

KW - CAS 23277-43-2

KW - Iontophoresis

KW - Nalbuphine

KW - Nalbuphine pivalate

KW - Transdermal drug delivery, diffusion

UR - http://www.scopus.com/inward/record.url?scp=0035018138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035018138&partnerID=8YFLogxK

M3 - Article

C2 - 11413742

AN - SCOPUS:0035018138

VL - 51

SP - 408

EP - 413

JO - Drug Research

JF - Drug Research

SN - 2194-9379

IS - 5

ER -