Transcranial Doppler Studies on Cerebral Autoregulation Suggest Prolonged Cerebral Vasoconstriction in a Subgroup of Patients with Orthostatic Intolerance

Ya Ju Lin, Helen L. Po, Hung Yi Hsu, Chih Ping Chung, Wen Yung Sheng, Han Hwa Hu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We studied the cerebral autoregulation in a subgroup of patients with orthostatic intolerance, who exhibited excessively decreased middle cerebral artery flow velocity (MCAFV) on transcranial Doppler sonography (TCD) during head-up tilt (HUT) test but without orthostatic hypotension or postural tachycardia. Twenty patients and 20 age- and sex-matched controls underwent Valsalva maneuver (VM) and HUT test with simultaneous monitoring of MCAFV by TCD and blood pressure, heart rate recordings. The pulsatility index (PI), cerebrovascular resistance (CVR) and autoregulatory indices were calculated. During HUT, patients had marked MCAFV reduction (-29.0 ± 5.25% vs. -8.01 ± 4.37%), paradoxically decreased PI (0.68 ± 0.17 vs. 0.96 ± 0.28) but increased CVR (45.7 ± 16.7% vs. 14.3 ± 12.6%). The MCAFV decreased similarly during early phase II of VM in both groups but did not recover to baseline in patients during late phase II, phase III and less overshoot in phase IV (-11 ± 16.7% vs. +2.2 ± 17.9 %; -15.4 ± 16.5% vs. -2.4 ± 17.8% and 16.7 ± 22.9% vs. 38.7 ± 26.5%, respectively). We concluded that in these patients, cerebrovascular vasoconstriction in response to physiologic stimulation was normal but relaxation during and after stimulation were impaired, indicating prolonged cerebral vasoconstriction.

Original languageEnglish
Pages (from-to)1554-1560
Number of pages7
JournalUltrasound in Medicine and Biology
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

Fingerprint

vasoconstriction
Orthostatic Intolerance
subgroups
Vasoconstriction
head up tilt
Middle Cerebral Artery
arteries
Homeostasis
Valsalva exercise
flow velocity
Doppler Transcranial Ultrasonography
Valsalva Maneuver
Head
stimulation
hypotension
tachycardia
blood pressure
heart rate
Orthostatic Hypotension
Tachycardia

Keywords

  • Cerebral autoregulation
  • Orthostatic intolerance
  • Tilt table
  • Transcranial Doppler ultrasonography
  • Valsalva maneuver

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Transcranial Doppler Studies on Cerebral Autoregulation Suggest Prolonged Cerebral Vasoconstriction in a Subgroup of Patients with Orthostatic Intolerance. / Lin, Ya Ju; Po, Helen L.; Hsu, Hung Yi; Chung, Chih Ping; Sheng, Wen Yung; Hu, Han Hwa.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 10, 01.10.2011, p. 1554-1560.

Research output: Contribution to journalArticle

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