Toxicity assessments of Chalcone and some Synthetic Chalcone Analogues in a Zebrafish model

Ya Ting Lee, Tsorng Harn Fong, Hui Min Chen, Chao Yuan Chang, Yun Hsin Wang, Ching Yuh Chern, Yau Hung Chen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a-d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.

Original languageEnglish
Pages (from-to)641-650
Number of pages10
JournalMolecules
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Chalcone
  • Embryogenesis
  • Muscle
  • Toxicity
  • Zebrafish

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

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    Lee, Y. T., Fong, T. H., Chen, H. M., Chang, C. Y., Wang, Y. H., Chern, C. Y., & Chen, Y. H. (2014). Toxicity assessments of Chalcone and some Synthetic Chalcone Analogues in a Zebrafish model. Molecules, 19(1), 641-650. https://doi.org/10.3390/molecules19010641