Total synthesis of NADH: ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

Sheng Tung Huang, Hsien Shou Kuo, Chien T. Chen

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17 Citations (Scopus)

Abstract

Concise synthesis of NADH:ubiquinone oxidoreductase (complex I) antagonist pterulone (1) and its analogue (2) are reported. Natural products 1 and 2 were prepared in four and five steps, respectively, from 5-bromosalicylaldehyde.

Original languageEnglish
Pages (from-to)7473-7475
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number42
DOIs
Publication statusPublished - Oct 15 2001

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Keywords

  • 1-benzoxepine
  • NADH:ubiquinone oxidoreductase
  • Pterulone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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