Abstract
A total synthesis of denbinobin (1) in seven steps with an overall yield of 10% is reported. This synthesis used an FeCl3-assisted cyclization of stilbene to form a phenanthrene. The poor yields of the decarboxylation and methoxylation steps were improved upon to become essentially quantitative. This scalable methodology was carried out using ordinary laboratory reagents.
| Original language | English |
|---|---|
| Pages (from-to) | 1170-1173 |
| Number of pages | 4 |
| Journal | Journal of Natural Products |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 22 2016 |
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Pharmaceutical Science
- Analytical Chemistry
- Organic Chemistry
- Molecular Medicine
- Complementary and alternative medicine