1 Citation (Scopus)

Abstract

Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To solve these problems, this study developed a novel scheme for synthesizing hispidulin, which had an improved overall yield as well as more concise reaction steps compared to previous methods reported. Additionally, using the same synthetic strategy, d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver microsome. This work may produce new chemical entities for enriching the library of hispidulin-derived compounds.

Original languageEnglish
Article number1897
JournalMolecules
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Derivatives
central nervous system
synthesis
liver
flavone
Neurology
Liver Microsomes
Liver
Libraries
Central Nervous System
hispidulin

Keywords

  • Deuterium-Labelled Compound
  • Flavone
  • Hispidulin
  • Microsome Stability
  • Total Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative. / Chen, Liang Chieh; Hsu, Kai Cheng; Chiou, Lih Chu; Tseng, Hui Ju; Huang, Wei Jan.

In: Molecules, Vol. 22, No. 11, 1897, 01.11.2017.

Research output: Contribution to journalArticle

Chen, Liang Chieh ; Hsu, Kai Cheng ; Chiou, Lih Chu ; Tseng, Hui Ju ; Huang, Wei Jan. / Total synthesis and metabolic stability of hispidulin and its d-labelled derivative. In: Molecules. 2017 ; Vol. 22, No. 11.
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