Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Liang Chieh Chen, Kai Cheng Hsu, Lih Chu Chiou, Hui Ju Tseng, Wei Jan Huang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To solve these problems, this study developed a novel scheme for synthesizing hispidulin, which had an improved overall yield as well as more concise reaction steps compared to previous methods reported. Additionally, using the same synthetic strategy, d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver microsome. This work may produce new chemical entities for enriching the library of hispidulin-derived compounds.

Original languageEnglish
Article number1897
Issue number11
Publication statusPublished - Nov 1 2017


  • Deuterium-Labelled Compound
  • Flavone
  • Hispidulin
  • Microsome Stability
  • Total Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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