Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis

Hong Nerng Ho, Ming Yih Wu, Shee Uan Chen, Kuang Han Chao, Chin Der Chen, Yu Shih Yang

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

To explore the role of nitric oxide (NO) and oxidative stress in the pathogenesis of adhesion formation and in endometriosis-associated infertility, we examined the peritoneal total antioxidant status (TAS) and the concentrations of products of NO metabolism in women with endometriosis (early stage, n = 12; advanced stage, n = 12) and in fertile women without endometriosis (n = 10). Peritoneal CA 125 and oestrogen and progesterone concentrations were also measured to examine their contributions to TAS and the production of NO. We failed to demonstrate any significant difference in TAS and in the products of NO metabolism in peritoneal fluids among women with early and advanced stages of endometriosis compared with fertile women without endometriosis during the early follicular phase. TAS and the concentration of the products of NO metabolism were not related to concentrations of CA 125, oestrogen or progesterone. The concentration of CA 125 in serum, but not in peritoneal fluid, was positively correlated with the severity of endometriosis. The volume of peritoneal fluid and the progesterone concentration were significantly increased in the group with advanced endometriosis. TAS and the concentration of the products of NO metabolism did not increase in peritoneal fluids from women with endometriosis during the early follicular phase. Their role in the pathophysiology of endometriosis needs to be explored further.

Original languageEnglish
Pages (from-to)2810-2815
Number of pages6
JournalHuman Reproduction
Volume12
Issue number12
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

Keywords

  • Antioxidants
  • CA 125
  • Endometriosis
  • Nitric oxide
  • Peritoneal fluid

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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