Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin, Chia Wen Ho, Leroy-Fong Liu, Yi Lisa Lyu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

Original languageEnglish
Pages (from-to)7182-7192
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
Publication statusPublished - Mar 8 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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