Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin, Chia Wen Ho, Leroy-Fong Liu, Yi Lisa Lyu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

Original languageEnglish
Pages (from-to)7182-7192
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
Publication statusPublished - Mar 8 2013
Externally publishedYes

Fingerprint

Camptothecin
Type II DNA Topoisomerase
Drug Delivery Systems
Apoptosis
RNA Polymerase II

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis. / Lin, Ren Kuo; Ho, Chia Wen; Liu, Leroy-Fong; Lyu, Yi Lisa.

In: Journal of Biological Chemistry, Vol. 288, No. 10, 08.03.2013, p. 7182-7192.

Research output: Contribution to journalArticle

Lin, Ren Kuo ; Ho, Chia Wen ; Liu, Leroy-Fong ; Lyu, Yi Lisa. / Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 10. pp. 7182-7192.
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