Topoisomerase i inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae

Jui Yu Wu, Ming Chih Chang, Chien Shu Chen, Hsiu Chen Lin, Hsiang Ping Tsai, Chien Chun Yang, Che Hsiung Yang, Chun Mao Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Topoisomerase inhibitors have been developed in a variety of clinical applications. We investigated the inhibitory effect of evodiamine on E. coli topoisomerase I, which may lead to an anti-bacterial effect. Evodiamine inhibits the supercoiled plasmid DNA relaxation that is catalyzed by E. coli topoisomerase I, and computer-aided docking has shown that the Arg161 and Asp551 residues of topoisomerase I interact with evodiamine. We investigated the bactericidal effect of evodiamine against multidrug-resistant Klebsiella pneumoniae. Evodiamine showed a significantly lower minimal inhibitory concentration value (MIC 128 μg/mL) compared with antibiotics (> 512 μg/mL) against the clinical isolate of K. pneumoniae. The results suggested that evodiamine is a potential agent against drug-resistant bacteria.

Original languageEnglish
Pages (from-to)27-29
Number of pages3
JournalPlanta Medica
Volume79
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • antibiotic
  • drug resistance
  • evodiamine
  • K. pneumonia
  • zopoisomerase

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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