Tocolysis and the risk of nonreassuring fetal status among pregnant women in labor: Findings from a population-based retrospective cohort study

I. Te Wang, Meng Ting Tsai, Steven R. Erickson, Chung Hsuen Wu

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.

Original languageEnglish
Pages (from-to)e18190
JournalMedicine
Volume98
Issue number50
DOIs
Publication statusPublished - Dec 1 2019

Fingerprint

Tocolysis
Fetal Distress
Pregnant Women
Cohort Studies
Uterine Contraction
Retrospective Studies
Population
Pregnancy
Logistic Models
National Health Programs
Taiwan
Odds Ratio
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tocolysis and the risk of nonreassuring fetal status among pregnant women in labor : Findings from a population-based retrospective cohort study. / Wang, I. Te; Tsai, Meng Ting; Erickson, Steven R.; Wu, Chung Hsuen.

In: Medicine, Vol. 98, No. 50, 01.12.2019, p. e18190.

Research output: Contribution to journalArticle

@article{0145cc99129c4f8ebbfa8e9ce932154b,
title = "Tocolysis and the risk of nonreassuring fetal status among pregnant women in labor: Findings from a population-based retrospective cohort study",
abstract = "The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6{\%}) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95{\%} Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.",
author = "Wang, {I. Te} and Tsai, {Meng Ting} and Erickson, {Steven R.} and Wu, {Chung Hsuen}",
year = "2019",
month = "12",
day = "1",
doi = "10.1097/MD.0000000000018190",
language = "English",
volume = "98",
pages = "e18190",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "50",

}

TY - JOUR

T1 - Tocolysis and the risk of nonreassuring fetal status among pregnant women in labor

T2 - Findings from a population-based retrospective cohort study

AU - Wang, I. Te

AU - Tsai, Meng Ting

AU - Erickson, Steven R.

AU - Wu, Chung Hsuen

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.

AB - The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.

UR - http://www.scopus.com/inward/record.url?scp=85077001354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077001354&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000018190

DO - 10.1097/MD.0000000000018190

M3 - Article

C2 - 31852074

AN - SCOPUS:85077001354

VL - 98

SP - e18190

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 50

ER -