TY - JOUR
T1 - Tocolysis and the risk of nonreassuring fetal status among pregnant women in labor
T2 - Findings from a population-based retrospective cohort study
AU - Wang, I. Te
AU - Tsai, Meng Ting
AU - Erickson, Steven R.
AU - Wu, Chung Hsuen
N1 - Funding Information:
Editor: Milan Perovic. This work was supported, in part, by a research grant from the National Science Council, Taiwan (NSC 102–2314-B-038–001, to Dr. Wu) and the Ministry of Science and Technology, Taiwan (MOST 105–2320-B-038–018, MOST 106– 2320-B-038–018 to Dr. Wu). The authors of this work have no conflicts of interest.
Publisher Copyright:
Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.
AB - The purpose of this study was to evaluate the association between tocolysis for preterm uterine contraction and the risk of nonreassuring fetal status.This was a retrospective cohort study using data from the Taiwan National Health Insurance Research Database. Pregnant women were enrolled if they delivered a baby during January 1, 2003 to December 31, 2011. The occurrence of the nonreassuring fetal status was compared between pregnant women with and without tocolytic treatment for preterm uterine contraction. Multivariable logistic regression models with adjusted cofounders were used to evaluate the association between tocolysis and the risk of nonreassuring fetal status.Of 24,133 pregnant women, 1115 (4.6%) received tocolytic treatment during pregnancy. After adjusting for covariates, pregnant women receiving tocolysis more than one time during pregnancy were found to have significantly higher risk of the nonreassuring fetal status when compared with pregnant women who did not receive tocolysis for uterine contraction (Odds Ratio = 2.70, 95% Confidence Interval: 1.13-6.49).Pregnant women with more frequent tocolysis for preterm uterine contraction during pregnancy had an increased risk of nonreassuring fetal status. Close evaluation of dose and duration of tocolytic treatment is necessary for pregnant women with preterm uterine contraction.
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U2 - 10.1097/MD.0000000000018190
DO - 10.1097/MD.0000000000018190
M3 - Article
C2 - 31852074
AN - SCOPUS:85077001354
SN - 0025-7974
VL - 98
SP - e18190
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
IS - 50
M1 - e18190
ER -