Tobacco consumption is a reversible risk factor associated with reduced successful treatment outcomes of anti-tuberculosis therapy

Yi Chun Chiang, You Meei Lin, Jen Ai Lee, Chun-Nin Lee, Hsiang Yin Chen

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Objective: The aim of this study was to evaluate the reversible factors that could possibly affect outcomes of anti-tuberculosis (anti-TB) treatment. Methods: A retrospective observational nested case-control study was performed to evaluate the association of patient and clinical factors with anti-TB therapy outcomes as defined by the World Health Organization (WHO). Results: To examine the impact of a variety of factors on the outcomes of anti-TB treatment, a total of 302 TB patients were included in the study. Univariate analysis revealed that age, gender, concurrent hypertension, asthma/chronic obstructive pulmonary disease, or liver disease, worsened baseline blood urea nitrogen or creatinine, ethambutol 20 cigarettes per day) was significantly associated with a decreased odds of cure or treatment completion (odds ratio 0.23, 95% confidence interval 0.05-0.98, p= 0.047). Conclusions: As smoking significantly inhibits the effectiveness of TB treatment, the integration of smoking cessation into TB treatment programs is strongly advocated to reduce the dual global burden of smoking and TB.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Drug therapy
  • Risk factors
  • Smoking
  • Treatment outcome
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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