TMC-151 a monoacetate, a new polyketide from Bionectria ochroleuca

Yu Ming Ju, Shin Hun Juang, Ke Jun Chen, Zong-Huei Li

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new polyketide, TMC-151 A monoacetate (1), along with a known analogue, TMC-151 F (2), was isolated from ethyl acetate extracts of the fermentation broth of Bionectria ochroleuca isolated in Taiwan. Their structures were elucidated on the basis of spectroscopic analysis. The antiproliferative activities of 1 and 2 were evaluated against MT-2 (human leukemia), A498 (human renal carcinoma), NPC-tw01 (human nasopharyngeal carcinoma), H-226 and A549 (non-small cell lung cancer) cell lines, and their IC50 values ranged from 18.3 to 40.2 μM.

Original languageEnglish
Pages (from-to)561-564
Number of pages4
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume62
Issue number4
Publication statusPublished - Apr 2007

Keywords

  • Bionectria ochroleuca
  • Cytotoxicity
  • Fermentation broth
  • Hypocreales
  • Polyketides

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry

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