Tissue microarray-determined expression profiles of SLIT2 in colorectal adenocarcinoma: Association with clinicopathological parameters

Yao Feng Li, Cheng Ping Yu, Ching Tzao, Jong Shiaw Jin

Research output: Contribution to journalArticle

Abstract

Accumulated evidence has revealed that increased SLIT2 expression is involved in several cancers, including hepatocellular carcinoma, recurrence of endometrioid adenocarcinoma, and prostate cancer. This study evaluated SLIT2 expression in colorectal cancers using tissue microarray analysis, and determined its association with clinicopathological stage. Immunohistochemical analysis of SLIT2 was performed in 194 specimens, including 181 primary colorectal adenocarcinomas (37 well differentiated, 103 moderately differentiated, and 41 poorly differentiated), and 13 samples of normal colonic epithelium. All colorectal adenocarcinomas showed significant immunohistochemical expression of SLIT2 when compared with normal colon epithelium. In multivariate analysis, the SLIT2 immunostaining score was significantly correlated with tumor differentiation and M stage, but not with T stage (P = 0.986), N stage (P = 0.840), and overall AJCC stage (P = 0.171). Furthermore, using SLIT2 scores as variable parameters, higher scores (≥ 300) were associated with higher mortality, and reach statistical significance (P = 0.043). Therefore, the development of pharmacological agents targeting the SLIT2 pathway may prolong survival and slow tumor progression in patients with colorectal adenocarcinoma.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalJournal of Medical Sciences (Taiwan)
Volume32
Issue number1
Publication statusPublished - 2012
Externally publishedYes

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Adenocarcinoma
Epithelium
Tissue Array Analysis
Endometrioid Carcinoma
Neoplasms
Hepatocellular Carcinoma
Colorectal Neoplasms
Prostatic Neoplasms
Colon
Multivariate Analysis
Pharmacology
Recurrence
Survival
Mortality

Keywords

  • Adenocarcinoma
  • Colorectal
  • SLIT 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tissue microarray-determined expression profiles of SLIT2 in colorectal adenocarcinoma : Association with clinicopathological parameters. / Li, Yao Feng; Yu, Cheng Ping; Tzao, Ching; Jin, Jong Shiaw.

In: Journal of Medical Sciences (Taiwan), Vol. 32, No. 1, 2012, p. 9-16.

Research output: Contribution to journalArticle

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