Tissue microarray analysis of interleukin-20 expression

Chung-Hsi Hsing, Chung Liang Ho, Lih Yun Chang, Yi Lin Lee, Shih Sung Chuang, Ming Shi Chang

Research output: Contribution to journalArticle

31 Citations (Scopus)


Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
Issue number1-2
Publication statusPublished - Jul 2006
Externally publishedYes


  • Cytokines
  • Interleukin-20
  • Tissue microarray

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

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  • Cite this

    Hsing, C-H., Ho, C. L., Chang, L. Y., Lee, Y. L., Chuang, S. S., & Chang, M. S. (2006). Tissue microarray analysis of interleukin-20 expression. Cytokine, 35(1-2), 44-52. https://doi.org/10.1016/j.cyto.2006.07.006