Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu, Yih Ming Wang, Long Sheng Lu, Chia Wei Sun, Chih Wei Lu, Meng Tsan Tsai, C. C. Yang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

Original languageEnglish
Article number064022
JournalJournal of Biomedical Optics
Volume12
Issue number6
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

Fingerprint

Birefringence
Optical tomography
Optical Coherence Tomography
liver
Liver
rats
birefringence
Rats
tomography
Polarization
Tissue
polarization
macrophages
Macrophages
infiltration
collagens
Infiltration
Collagen
causes

Keywords

  • Liver
  • Optical coherence tomography
  • Tissue birefringence

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

Cite this

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography. / Wu, Chau Chung; Wang, Yih Ming; Lu, Long Sheng; Sun, Chia Wei; Lu, Chih Wei; Tsai, Meng Tsan; Yang, C. C.

In: Journal of Biomedical Optics, Vol. 12, No. 6, 064022, 11.2007.

Research output: Contribution to journalArticle

Wu, Chau Chung ; Wang, Yih Ming ; Lu, Long Sheng ; Sun, Chia Wei ; Lu, Chih Wei ; Tsai, Meng Tsan ; Yang, C. C. / Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography. In: Journal of Biomedical Optics. 2007 ; Vol. 12, No. 6.
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