Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case-Control Study

Yen Chu Huang, Ting Chun Lin, Jiann Der Lee, Ya Hui Lin, Rey Yue Yuan, Hsu Huei Weng, Ying Chih Huang, Meng Lee, Chih Ying Wu, Huan Lin Hsu, Chia Yu Hsu, Tsong Hai Lee, Shan Jin Liu, Yeu Jhy Chang, Chien Hung Chang, Tsung I. Peng, Chia Wei Liou, Ku Chou Chang, Yi Ting Pan

Research output: Contribution to journalArticle

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Abstract

Background: The risk of symptomatic infarct swelling has been reported to be higher in patients treated with recombinant tissue plasminogen activator (rt-PA). The aim of this study was to evaluate the timing of symptomatic infarct swelling after rt-PA treatment. Methods: We retrospectively analyzed 14 868 patients with acute ischemic stroke from a stroke registry databank. We recruited patients with massive middle cerebral artery (MCA) infarction and symptomatic infarct swelling and excluded those with parenchymal or symptomatic hemorrhage. Multiple linear regression and multivariate logistic regression analyses were used to estimate the impact of rt-PA on the timing of symptomatic infarct swelling. Results: A total of 23 patients with rt-PA treatment and 117 patients without rt-PA treatment were included. The rt-PA treatment group had a lower rate of coronary artery disease (8.7% vs 32.5%; P =.023), lower severity of baseline National Institutes of Health Stroke Scale score (19 vs 23; P =.014), shorter duration of infarct swelling (27.6 vs 45.4 hours; P <.001), and higher rate of hemicraniectomy surgery (65.2% vs 28.2%; P =.001) than those without rt-PA treatment. After adjusting for variables in multiple linear regression analysis, rt-PA treatment and an elevated C-reactive protein level were associated with early symptomatic infarct swelling (P =.014 and P =.041, respectively). The rt-PA treatment was an independent factor related to early symptomatic infarct swelling within 36 hours (P =.005; odds ratio [OR]: 5.3; confidence interval [CI]: 1.65-17.0) or 48 hours (P =.009; OR: 16.4; CI: 2.00-134). Conclusion: Intravenous rt-PA treatment may hasten the onset of cerebral edema and subsequent cerebral herniation in large MCA territory infarction.

Original languageEnglish
Pages (from-to)814-820
Number of pages7
JournalClinical and Applied Thrombosis/Hemostasis
Volume23
Issue number7
DOIs
Publication statusPublished - Oct 1 2017

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Middle Cerebral Artery Infarction
Tissue Plasminogen Activator
Case-Control Studies
Stroke
Therapeutics
Linear Models
Odds Ratio
Regression Analysis
Confidence Intervals
Brain Edema
National Institutes of Health (U.S.)
C-Reactive Protein
Registries
Coronary Artery Disease
Logistic Models
Databases
Hemorrhage

Keywords

  • edema
  • infarction
  • middle cerebral artery occlusion
  • thrombolysis

ASJC Scopus subject areas

  • Hematology

Cite this

Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction : A Case-Control Study. / Huang, Yen Chu; Lin, Ting Chun; Lee, Jiann Der; Lin, Ya Hui; Yuan, Rey Yue; Weng, Hsu Huei; Huang, Ying Chih; Lee, Meng; Wu, Chih Ying; Hsu, Huan Lin; Hsu, Chia Yu; Lee, Tsong Hai; Liu, Shan Jin; Chang, Yeu Jhy; Chang, Chien Hung; Peng, Tsung I.; Liou, Chia Wei; Chang, Ku Chou; Pan, Yi Ting.

In: Clinical and Applied Thrombosis/Hemostasis, Vol. 23, No. 7, 01.10.2017, p. 814-820.

Research output: Contribution to journalArticle

Huang, YC, Lin, TC, Lee, JD, Lin, YH, Yuan, RY, Weng, HH, Huang, YC, Lee, M, Wu, CY, Hsu, HL, Hsu, CY, Lee, TH, Liu, SJ, Chang, YJ, Chang, CH, Peng, TI, Liou, CW, Chang, KC & Pan, YT 2017, 'Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case-Control Study', Clinical and Applied Thrombosis/Hemostasis, vol. 23, no. 7, pp. 814-820. https://doi.org/10.1177/1076029616659693
Huang, Yen Chu ; Lin, Ting Chun ; Lee, Jiann Der ; Lin, Ya Hui ; Yuan, Rey Yue ; Weng, Hsu Huei ; Huang, Ying Chih ; Lee, Meng ; Wu, Chih Ying ; Hsu, Huan Lin ; Hsu, Chia Yu ; Lee, Tsong Hai ; Liu, Shan Jin ; Chang, Yeu Jhy ; Chang, Chien Hung ; Peng, Tsung I. ; Liou, Chia Wei ; Chang, Ku Chou ; Pan, Yi Ting. / Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction : A Case-Control Study. In: Clinical and Applied Thrombosis/Hemostasis. 2017 ; Vol. 23, No. 7. pp. 814-820.
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abstract = "Background: The risk of symptomatic infarct swelling has been reported to be higher in patients treated with recombinant tissue plasminogen activator (rt-PA). The aim of this study was to evaluate the timing of symptomatic infarct swelling after rt-PA treatment. Methods: We retrospectively analyzed 14 868 patients with acute ischemic stroke from a stroke registry databank. We recruited patients with massive middle cerebral artery (MCA) infarction and symptomatic infarct swelling and excluded those with parenchymal or symptomatic hemorrhage. Multiple linear regression and multivariate logistic regression analyses were used to estimate the impact of rt-PA on the timing of symptomatic infarct swelling. Results: A total of 23 patients with rt-PA treatment and 117 patients without rt-PA treatment were included. The rt-PA treatment group had a lower rate of coronary artery disease (8.7{\%} vs 32.5{\%}; P =.023), lower severity of baseline National Institutes of Health Stroke Scale score (19 vs 23; P =.014), shorter duration of infarct swelling (27.6 vs 45.4 hours; P <.001), and higher rate of hemicraniectomy surgery (65.2{\%} vs 28.2{\%}; P =.001) than those without rt-PA treatment. After adjusting for variables in multiple linear regression analysis, rt-PA treatment and an elevated C-reactive protein level were associated with early symptomatic infarct swelling (P =.014 and P =.041, respectively). The rt-PA treatment was an independent factor related to early symptomatic infarct swelling within 36 hours (P =.005; odds ratio [OR]: 5.3; confidence interval [CI]: 1.65-17.0) or 48 hours (P =.009; OR: 16.4; CI: 2.00-134). Conclusion: Intravenous rt-PA treatment may hasten the onset of cerebral edema and subsequent cerebral herniation in large MCA territory infarction.",
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T1 - Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction

T2 - A Case-Control Study

AU - Huang, Yen Chu

AU - Lin, Ting Chun

AU - Lee, Jiann Der

AU - Lin, Ya Hui

AU - Yuan, Rey Yue

AU - Weng, Hsu Huei

AU - Huang, Ying Chih

AU - Lee, Meng

AU - Wu, Chih Ying

AU - Hsu, Huan Lin

AU - Hsu, Chia Yu

AU - Lee, Tsong Hai

AU - Liu, Shan Jin

AU - Chang, Yeu Jhy

AU - Chang, Chien Hung

AU - Peng, Tsung I.

AU - Liou, Chia Wei

AU - Chang, Ku Chou

AU - Pan, Yi Ting

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: The risk of symptomatic infarct swelling has been reported to be higher in patients treated with recombinant tissue plasminogen activator (rt-PA). The aim of this study was to evaluate the timing of symptomatic infarct swelling after rt-PA treatment. Methods: We retrospectively analyzed 14 868 patients with acute ischemic stroke from a stroke registry databank. We recruited patients with massive middle cerebral artery (MCA) infarction and symptomatic infarct swelling and excluded those with parenchymal or symptomatic hemorrhage. Multiple linear regression and multivariate logistic regression analyses were used to estimate the impact of rt-PA on the timing of symptomatic infarct swelling. Results: A total of 23 patients with rt-PA treatment and 117 patients without rt-PA treatment were included. The rt-PA treatment group had a lower rate of coronary artery disease (8.7% vs 32.5%; P =.023), lower severity of baseline National Institutes of Health Stroke Scale score (19 vs 23; P =.014), shorter duration of infarct swelling (27.6 vs 45.4 hours; P <.001), and higher rate of hemicraniectomy surgery (65.2% vs 28.2%; P =.001) than those without rt-PA treatment. After adjusting for variables in multiple linear regression analysis, rt-PA treatment and an elevated C-reactive protein level were associated with early symptomatic infarct swelling (P =.014 and P =.041, respectively). The rt-PA treatment was an independent factor related to early symptomatic infarct swelling within 36 hours (P =.005; odds ratio [OR]: 5.3; confidence interval [CI]: 1.65-17.0) or 48 hours (P =.009; OR: 16.4; CI: 2.00-134). Conclusion: Intravenous rt-PA treatment may hasten the onset of cerebral edema and subsequent cerebral herniation in large MCA territory infarction.

AB - Background: The risk of symptomatic infarct swelling has been reported to be higher in patients treated with recombinant tissue plasminogen activator (rt-PA). The aim of this study was to evaluate the timing of symptomatic infarct swelling after rt-PA treatment. Methods: We retrospectively analyzed 14 868 patients with acute ischemic stroke from a stroke registry databank. We recruited patients with massive middle cerebral artery (MCA) infarction and symptomatic infarct swelling and excluded those with parenchymal or symptomatic hemorrhage. Multiple linear regression and multivariate logistic regression analyses were used to estimate the impact of rt-PA on the timing of symptomatic infarct swelling. Results: A total of 23 patients with rt-PA treatment and 117 patients without rt-PA treatment were included. The rt-PA treatment group had a lower rate of coronary artery disease (8.7% vs 32.5%; P =.023), lower severity of baseline National Institutes of Health Stroke Scale score (19 vs 23; P =.014), shorter duration of infarct swelling (27.6 vs 45.4 hours; P <.001), and higher rate of hemicraniectomy surgery (65.2% vs 28.2%; P =.001) than those without rt-PA treatment. After adjusting for variables in multiple linear regression analysis, rt-PA treatment and an elevated C-reactive protein level were associated with early symptomatic infarct swelling (P =.014 and P =.041, respectively). The rt-PA treatment was an independent factor related to early symptomatic infarct swelling within 36 hours (P =.005; odds ratio [OR]: 5.3; confidence interval [CI]: 1.65-17.0) or 48 hours (P =.009; OR: 16.4; CI: 2.00-134). Conclusion: Intravenous rt-PA treatment may hasten the onset of cerebral edema and subsequent cerebral herniation in large MCA territory infarction.

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