Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101

Yueh Ting Tsai, Po Ching Cheng, Chia Kwung Fan, Tzu Ming Pan

Research output: Contribution to journalArticle

53 Citations (Scopus)


The possible time-dependent role of lactic acid bacteria (LAB) in immunomodulation was investigated in BALB/c mice fed daily with Lactobacillus paracasei subsp. paracasei NTU 101 (108 colony forming units) for 3, 6, and 9 weeks, and following feeding with Lactobacillus-free food for a further 7 days. We observed up-regulation of the antigen-presenting ability of dendritic cells, and expression of natural killer group-2 D (NKG2D) molecules capable of trigger natural killer cell-mediated cytotoxicity. Lymphocyte proliferation and antibody production were also significantly increased in mice after treatment. Innate and adaptive immunity remained constant even at the most protracted feeding time, indicative of the time dependence of the bacterial-mediated enhanced immunity. To better correlate intestinal microflora with immunity, the intestinal contents of probiotics and harmful microorganisms were determined. Results showed an altered intestinal microflora, with increases in bifidobacteria and lactobacilli and a decreased content of Clostridium perfringens after feeding with L. paracasei subsp. paracasei NTU 101. It is possible that persistent activation of immunity might be induced by intestinal probiotics.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalInternational Journal of Food Microbiology
Issue number2
Publication statusPublished - Dec 10 2008



  • Immunomodulation
  • Innate immune response
  • Lactic acid bacteria
  • Lactobacillus paracasei subsp. paracasei NTU 101

ASJC Scopus subject areas

  • Food Science
  • Safety, Risk, Reliability and Quality
  • Microbiology

Cite this