Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade

Chun Nun Chao, Jeng Fan Lo, Farheen B. Khan, Cecilia H. Day, Chao Hung Lai, Chia Hua Chen, Ray Jade Chen, Vijaya P. Viswanadha, Chia Hua Kuo, Chih Yang Huang

Research output: Contribution to journalArticle

Abstract

Myocardial dysfunction is clinically relevant? repercussion that follows sepsis. Tid 1 protein has been implicated in many biological process. However, the role of Tid 1 in lipopolysaccharide (LPS)-induced cardiomyocyte hypertrophy and apoptosis remains elusive. In the current research endeavor, we have elucidated the role of Tid1-S on LPS-induced cardiac hypertrophy and apoptosis. Interestingly, we found that overexpression of Tid1-S suppressed TLR-4, NFATc3, and BNP protein expression which eventually led to inhibition of LPS-induced cardiac hypertrophy. Moreover, Tid1-S overexpression attenuated cellular apoptosis and activated survival proteins p-PI3K and pser473Akt. Besides this, Tid1-S overexpression enhanced ER-a protein expression. Collectively, our data suggest that Tid1-S plausibly enhance ER-a protein and further activate p-PI3K and p ser473Akt survival protein expression; which thereby led to attenuation of LPS-induced apoptosis in cardiomyoblast cells. Interestingly, our data suggest that Tid1-S is involved in attenuation of cardiomyoblast cells damages induced by LPS.

Original languageEnglish
Pages (from-to)16703-16710
Number of pages8
JournalJournal of Cellular Biochemistry
Volume120
Issue number10
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Akt
  • H9c2
  • LPS
  • PI3K
  • Tid-1S

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Chao, C. N., Lo, J. F., Khan, F. B., Day, C. H., Lai, C. H., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, C. H., & Huang, C. Y. (2019). Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade. Journal of Cellular Biochemistry, 120(10), 16703-16710. https://doi.org/10.1002/jcb.28928