Thyroid metastasis in a patient with hepatocellular carcinoma: Case report and review of literature

Hung Hua Liang, Chih Hsiung Wu, Ka Wai Tam, Chiah Yang Chai, Sey En Lin, Soul-Chin Chen

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: Despite the apparent low incidence of cancer metastatic to the thyroid, autopsy and clinical series suggest it is more common than generally. Although lung, renal, and breast cancer are probably the most common primary sites, a number of cancers have been reported to metastasize to the thyroid synchronously with diagnosis of primary tumor or years after apparently curative treatment. Case presentation: We report a rare case of a hepatocellular carcinoma metasatic to the thyroid. The patient presented seven months after original diagnosis and treatment with hepatic lobectomy with multiple neck lesions producing a mass effect on the trachea and bilateral lymphadenopathy. Fine-needle aspiration revealed highly anaplastic carcinoma, and immunohistochemistry confirmed hepatocellular carcinoma. The patient received total thyroidectomy as palliative therapy because of the presence of multiple recurrent lesions in the liver. Conclusion: Clinicians should consider the possibility of metastatic cancer in each patient who presents with a new thyroid mass, especially those with a history of cancer, however remote. In cases where cytology or histology is not diagnostic, immunohistochemistry may be definitive in making the diagnosis.

Original languageEnglish
Article number144
JournalWorld Journal of Surgical Oncology
Volume5
DOIs
Publication statusPublished - Dec 24 2007

ASJC Scopus subject areas

  • Cancer Research
  • Surgery

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