Thyroid Hormone, Cancer, and Apoptosis

Hung Yun Lin, Yu Tan Chin, Yu Chen S.H. Yang, Husan Yu Lai, Jacqueline Wang-Peng, Leory F. Liu, Heng Yuan Tang, Paul J. Davis

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Thyroid hormones play important roles in regulating normal metabolism, development, and growth. They also stimulate cancer cell proliferation. Their metabolic and developmental effects and growth effects in normal tissues are mediated primarily by nuclear hormone receptors. A cell surface receptor for the hormone on integrin [alpha]vβ3 is the initiation site for effects on tumor cells. Clinical hypothyroidism may retard cancer growth, and hyperthyroidism was recently linked to the prevalence of certain cancers. Local levels of thyroid hormones are controlled through activation and deactivation of iodothyronine deiodinases in different organs. The relative activities of different deiodinases that exist in tissues or organs also affect the progression and development of specific types of cancers. In this review, the effects of thyroid hormone on signaling pathways in breast, brain, liver, thyroid, and colon cancers are discussed. The importance of nuclear thyroid hormone receptor isoforms and of the hormone receptor on the extracellular domain of integrin [alpha]vβ3 as potential cancer risk factors and therapeutic targets are addressed. We analyze the intracellular signaling pathways activated by thyroid hormones in cancer progression in hyperthyroidism or at physiological concentrations in the euthyroid state. Determining how to utilize the deaminated thyroid hormone analog (tetrac), and its nanoparticulate derivative to reduce risks of cancer progression, enhance therapeutic outcomes, and prevent cancer recurrence is also deliberated.

Original languageEnglish
Pages (from-to)1221-1237
Number of pages17
JournalComprehensive Physiology
Volume6
Issue number3
DOIs
Publication statusPublished - Jun 13 2016

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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  • Cite this

    Lin, H. Y., Chin, Y. T., Yang, Y. C. S. H., Lai, H. Y., Wang-Peng, J., Liu, L. F., Tang, H. Y., & Davis, P. J. (2016). Thyroid Hormone, Cancer, and Apoptosis. Comprehensive Physiology, 6(3), 1221-1237. https://doi.org/10.1002/cphy.c150035