Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas

Syu Jyun Peng, Tomor Harnod, Jang Zern Tsai, Chien Chun Huang, Ming Dou Ker, Jun Chern Chiou, Herming Chiueh, Chung Yu Wu, Yue Loong Hsin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with high-resolution and diffusion tensor MRIs. Automated demarcation of supratentorial fibers was accomplished with personalized fiber-labeled atlases. From the individual atlases, we observed significant elevation of mean diffusivity (MD) in fornix (cres)/stria terminalis (FX/ST) and sagittal stratum (SS) and a significant difference in fractional anisotropy (FA) among FX/ST, SS, posterior limb of the internal capsule (PLIC), and posterior thalamic radiation (PTR). For patients with early-onset epilepsy, the diffusivities of the SS and the retrolenticular part of the internal capsule were significantly elevated, and the anisotropies of the FX/ST and SS were significantly decreased. In the drug-resistant subgroup, the MDs of SS and PTR and the FAs of SS and PLIC were significantly different. Onset age was positively correlated with increases in FAs of the genu of the corpus callosum. Patients with neocortical seizures and secondary generalisation had microstructural anomalies in WM. The changes in WM are relevant to early onset, progression, and severity of epilepsy.

Original languageEnglish
Article number419376
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Neural Pathways
Diffusion Magnetic Resonance Imaging
Atlases
Magnetic resonance
Internal Capsule
Capsules
Tensors
Seizures
Imaging techniques
Epilepsy
Anisotropy
Radiation
Extremities
Fibers
Magnetic resonance imaging
Corpus Callosum
Age of Onset
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations
White Matter

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas. / Peng, Syu Jyun; Harnod, Tomor; Tsai, Jang Zern; Huang, Chien Chun; Ker, Ming Dou; Chiou, Jun Chern; Chiueh, Herming; Wu, Chung Yu; Hsin, Yue Loong.

In: BioMed Research International, Vol. 2014, 419376, 01.01.2014.

Research output: Contribution to journalArticle

Peng, Syu Jyun ; Harnod, Tomor ; Tsai, Jang Zern ; Huang, Chien Chun ; Ker, Ming Dou ; Chiou, Jun Chern ; Chiueh, Herming ; Wu, Chung Yu ; Hsin, Yue Loong. / Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas. In: BioMed Research International. 2014 ; Vol. 2014.
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