Thrombophilia in patients with hypertriglyceridemia

Paul Chan, Tsuei Yuan Huang, Shyh Ming Shieh, Tz Shing Lin, Chung Wen Tsai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: To investigate a possible relationship between hypertriglyceridemia and the coagulation system, a Cardiovascular Risk Factor Two-township Study was conducted in Taiwan. Design: A case-control study. This longitudinal, prospective study focused on the evolution of cardiovascular disease risk factors with emphasis on haemostatic factors. Subjects: Hypertriglyceridemic subjects (triglyceride > 2.26 mmoll -1, n = 327) and age-matched normal controls from a population screening program. Main outcome measures: Haemostatic parameters measured in this study included prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, factors VIIc and VIIIc, and antithrombin-III and plasminogen levels. Results: In our male hypertriglyceridemic subjects, aPTT was not significantly reduced, while significant elevations of factor VIIIc, factor VIIc, and plasminogen and antithrombin-III levels were noted. In the female hypertriglyceridemic subjects, the elevation of factor VIIc, factor VIIIc, and plasminogen and antithrombin-III levels was highly-significant, whereas aPTT was not significantly reduced. Unexpectedly, the levels of the established coronary risk factor, fibrinogen, did not show a statistically different change. Similar to previous data, our hypertriglyceridemic subjects also presented with hyperinsulinemia, glucose intolerance, upper body obesity, and elevated blood pressure. Conclusions: Despite the fact that in population studies, triglycerides do not consistently appear to be an independent risk factor for coronary heart disease, our data suggest that a pronounced increase in triglycerides warrants aggressive therapy, because this increase may be associated with a hypercoagulable state. This phenomenon contributes another perspective to the study of higher cardiovascular mortality in hypertriglyceridemic subjects.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Volume4
Issue number3-4
DOIs
Publication statusPublished - 1997

Fingerprint

Thrombophilia
Hypertriglyceridemia
Antithrombin III
Partial Thromboplastin Time
Plasminogen
Triglycerides
Hemostatics
Fibrinogen
Glucose Intolerance
Population Control
Prothrombin Time
Hyperinsulinism
Cardiovascular System
Taiwan
Coronary Disease
Longitudinal Studies
Case-Control Studies
Cardiovascular Diseases
Obesity
Outcome Assessment (Health Care)

Keywords

  • Coagulation factors
  • Coronary heart disease
  • Hypertriglyceridemia

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Thrombophilia in patients with hypertriglyceridemia. / Chan, Paul; Huang, Tsuei Yuan; Shieh, Shyh Ming; Lin, Tz Shing; Tsai, Chung Wen.

In: Journal of Thrombosis and Thrombolysis, Vol. 4, No. 3-4, 1997, p. 425-429.

Research output: Contribution to journalArticle

Chan, Paul ; Huang, Tsuei Yuan ; Shieh, Shyh Ming ; Lin, Tz Shing ; Tsai, Chung Wen. / Thrombophilia in patients with hypertriglyceridemia. In: Journal of Thrombosis and Thrombolysis. 1997 ; Vol. 4, No. 3-4. pp. 425-429.
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