Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients

Ming Jui Hung, Ning I. Yang, I. Wen Wu, Chi Wen Cheng, Ping Chang Liu, Shih Jen Chen, Mai Szu Wu, Wen Jin Cherng

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate the relations of left ventricular (LV) mass and geometry to LV function in patients with predialysis chronic kidney disease (CKD), by real-time 3-dimensional echocardiography (RT3-DE). Methods: Echocardiography was performed on 76 consecutively enrolled patients (51 men) with different stages of CKD, including 26 patients with mild CKD (CKD stages 1-2) and 50 patients with moderate-tosevere CKD (CKD stages 3-5). LV mass and LV enddiastolic volume were measured by RT3-DE. Results: Greater prevalence of LV diastolic dysfunction and higher mitral E/myocardial velocities in early diastole (Em) values were noted in patients with moderate-to-severe CKD. In the moderate-tosevere CKD group, patients with increased LV mass had lower myocardial velocities in peak systole (Sm) and longer isovolumic relaxation time (IVRT). In the mild CKD group, patients with increased LV mass to volume ratios had lower Em. Moderate-to-severe CKD was associated with lower Sm and Em and higher mitral rapid filling to Em (E/Em) ratios by LV mass quartile stratification. Using LV mass/volume quartile stratification, moderate-to-severe CKD was associated with longer IVRT, lower Sm and higher mitral E/Em. Multivariable logistic regression analysis showed that CKD severity was the most independent predictor of elevated LV filling pressure (odds ratio = 2.96, p=0.019). Conclusions: Increased LV mass impaired LV contraction and relaxation in patients with moderate-to-severe CKD. Concentric remodeling impaired LV diastolic function in patients with mild CKD. CKD severity was positively associated with elevated LV filling pressure.

Original languageEnglish
Pages (from-to)96-106
Number of pages11
JournalJournal of Nephrology
Volume25
Issue number1
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

Fingerprint

Ventricular Remodeling
Chronic Renal Insufficiency
Echocardiography
Ventricular Pressure
Left Ventricular Function
Diastole
Systole
Left Ventricular Dysfunction

Keywords

  • Chronic kidney disease
  • Left ventricle
  • Remodeling
  • Three-dimensional echocardiography

ASJC Scopus subject areas

  • Nephrology

Cite this

Hung, M. J., Yang, N. I., Wu, I. W., Cheng, C. W., Liu, P. C., Chen, S. J., ... Cherng, W. J. (2012). Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients. Journal of Nephrology, 25(1), 96-106. https://doi.org/10.5301/JN.2011.8352

Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients. / Hung, Ming Jui; Yang, Ning I.; Wu, I. Wen; Cheng, Chi Wen; Liu, Ping Chang; Chen, Shih Jen; Wu, Mai Szu; Cherng, Wen Jin.

In: Journal of Nephrology, Vol. 25, No. 1, 02.2012, p. 96-106.

Research output: Contribution to journalArticle

Hung, Ming Jui ; Yang, Ning I. ; Wu, I. Wen ; Cheng, Chi Wen ; Liu, Ping Chang ; Chen, Shih Jen ; Wu, Mai Szu ; Cherng, Wen Jin. / Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients. In: Journal of Nephrology. 2012 ; Vol. 25, No. 1. pp. 96-106.
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AU - Hung, Ming Jui

AU - Yang, Ning I.

AU - Wu, I. Wen

AU - Cheng, Chi Wen

AU - Liu, Ping Chang

AU - Chen, Shih Jen

AU - Wu, Mai Szu

AU - Cherng, Wen Jin

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N2 - Background: The aim of this study was to investigate the relations of left ventricular (LV) mass and geometry to LV function in patients with predialysis chronic kidney disease (CKD), by real-time 3-dimensional echocardiography (RT3-DE). Methods: Echocardiography was performed on 76 consecutively enrolled patients (51 men) with different stages of CKD, including 26 patients with mild CKD (CKD stages 1-2) and 50 patients with moderate-tosevere CKD (CKD stages 3-5). LV mass and LV enddiastolic volume were measured by RT3-DE. Results: Greater prevalence of LV diastolic dysfunction and higher mitral E/myocardial velocities in early diastole (Em) values were noted in patients with moderate-to-severe CKD. In the moderate-tosevere CKD group, patients with increased LV mass had lower myocardial velocities in peak systole (Sm) and longer isovolumic relaxation time (IVRT). In the mild CKD group, patients with increased LV mass to volume ratios had lower Em. Moderate-to-severe CKD was associated with lower Sm and Em and higher mitral rapid filling to Em (E/Em) ratios by LV mass quartile stratification. Using LV mass/volume quartile stratification, moderate-to-severe CKD was associated with longer IVRT, lower Sm and higher mitral E/Em. Multivariable logistic regression analysis showed that CKD severity was the most independent predictor of elevated LV filling pressure (odds ratio = 2.96, p=0.019). Conclusions: Increased LV mass impaired LV contraction and relaxation in patients with moderate-to-severe CKD. Concentric remodeling impaired LV diastolic function in patients with mild CKD. CKD severity was positively associated with elevated LV filling pressure.

AB - Background: The aim of this study was to investigate the relations of left ventricular (LV) mass and geometry to LV function in patients with predialysis chronic kidney disease (CKD), by real-time 3-dimensional echocardiography (RT3-DE). Methods: Echocardiography was performed on 76 consecutively enrolled patients (51 men) with different stages of CKD, including 26 patients with mild CKD (CKD stages 1-2) and 50 patients with moderate-tosevere CKD (CKD stages 3-5). LV mass and LV enddiastolic volume were measured by RT3-DE. Results: Greater prevalence of LV diastolic dysfunction and higher mitral E/myocardial velocities in early diastole (Em) values were noted in patients with moderate-to-severe CKD. In the moderate-tosevere CKD group, patients with increased LV mass had lower myocardial velocities in peak systole (Sm) and longer isovolumic relaxation time (IVRT). In the mild CKD group, patients with increased LV mass to volume ratios had lower Em. Moderate-to-severe CKD was associated with lower Sm and Em and higher mitral rapid filling to Em (E/Em) ratios by LV mass quartile stratification. Using LV mass/volume quartile stratification, moderate-to-severe CKD was associated with longer IVRT, lower Sm and higher mitral E/Em. Multivariable logistic regression analysis showed that CKD severity was the most independent predictor of elevated LV filling pressure (odds ratio = 2.96, p=0.019). Conclusions: Increased LV mass impaired LV contraction and relaxation in patients with moderate-to-severe CKD. Concentric remodeling impaired LV diastolic function in patients with mild CKD. CKD severity was positively associated with elevated LV filling pressure.

KW - Chronic kidney disease

KW - Left ventricle

KW - Remodeling

KW - Three-dimensional echocardiography

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