Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas

Yu Tang Tung, Hsiao Ling Chen, Hsin Chung Tsai, Shang Hsun Yang, Yi Chun Chang, Chuan Mu Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Andrographolide is one of the major diterpene lactones found in Andrographis paniculata Nees and exhibits remarkable inhibitory effects on various cancers. In this study, the antipulmonary cancer effects of andrographolide were studied in a lung tumor mouse model induced by human vascular endothelial growth factor A165 (hVEGF-A165). These results demonstrated that andrographolide significantly reduced the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs. In addition, andrographolide also decreased tumor formation by reducing VEGF, EGFR, Cyclin A, and Cyclin B expression on the transcriptional and translational levels. These results indicated that andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice. In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future.

Original languageEnglish
Article number305898
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Andrographis
Neoplasms
Lung
Vascular Endothelial Growth Factor A
Therapeutics
Cyclin B
Cyclin A
Diterpenes
Lactones
Cell Cycle Checkpoints
Transgenic Mice
Adenocarcinoma of lung
andrographolide

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas. / Tung, Yu Tang; Chen, Hsiao Ling; Tsai, Hsin Chung; Yang, Shang Hsun; Chang, Yi Chun; Chen, Chuan Mu.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2013, 305898, 2013.

Research output: Contribution to journalArticle

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