Therapeutic plasma exchange in the treatment of complicated Plasmodium falciparum malaria

A case report

Tsong Yih Ou, Cheng Yen Chuang, Chun Da Chen, Chung Yi Cheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Severe falciparum malaria is associated with multiple organ dysfunction and a high rate of fatal outcome. Malaria is a world-wide disease in tropical areas through the bites of vector mosquitoes. Parasitic protozoans introduced by the mosquito's saliva to the blood travel to the liver then mature and reproduce. In humans, malaria is caused by Plasmodium falciparum, P. malariae, P. ovale, P. vivax, and P. knowlesi, and P. falciparum causes most deaths. Typical malaria symptoms include fever, chills, fatigue, headache, nausea, and vomiting. In severe cases, it can cause jaundice, seizures, coma, or death. Jaundice, caused by intravascular hemolysis is a usual complication of malaria, especially in patients with P. falciparum infection. The use of exchange transfusion in malaria is not currently advocated by the Centers of Disease Control and Prevention (CDC) of the United States of America. The role of therapeutic plasma exchange as an adjunctive therapy in malaria has not been widely discussed in the literature. Here, we present a 23-year-old patient with jaundice, acute renal failure, and cerebral involvement who was successfully treated with plasma exchange and hemodialysis.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalJournal of Clinical Apheresis
Volume33
Issue number3
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Plasma Exchange
Falciparum Malaria
Malaria
Jaundice
Plasmodium falciparum
Therapeutics
Chills
Fatal Outcome
Bites and Stings
Centers for Disease Control and Prevention (U.S.)
Coma
Hemolysis
Culicidae
Saliva
Acute Kidney Injury
Nausea
Vomiting
Fatigue
Headache
Renal Dialysis

Keywords

  • hyperbilirubinemia
  • jaundice
  • malaria
  • plasma exchange

ASJC Scopus subject areas

  • Hematology

Cite this

Therapeutic plasma exchange in the treatment of complicated Plasmodium falciparum malaria : A case report. / Ou, Tsong Yih; Chuang, Cheng Yen; Chen, Chun Da; Cheng, Chung Yi.

In: Journal of Clinical Apheresis, Vol. 33, No. 3, 01.06.2018, p. 419-422.

Research output: Contribution to journalArticle

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