Therapeutic applications of targeted alternative splicing to cancer treatment

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9 Citations (Scopus)

Abstract

A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers
Original languageEnglish
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2018

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splicing
Oncology
Alternative Splicing
Protein Isoforms
cancer
Neoplasms
regulators
Therapeutics
biology
Drug Resistance
Pharmaceutical Preparations
therapy
drugs
routes

Cite this

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title = "Therapeutic applications of targeted alternative splicing to cancer treatment",
abstract = "A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers",
author = "Jung-Chun Lin",
year = "2018",
language = "English",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",

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TY - JOUR

T1 - Therapeutic applications of targeted alternative splicing to cancer treatment

AU - Lin, Jung-Chun

PY - 2018

Y1 - 2018

N2 - A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers

AB - A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers

M3 - Review article

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

ER -