The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: A hospital-based matched case-control study

Nuntiput Putthanachote, Supannee Promthet, Cameron Hurst, Krittika Suwanrungruang, Peechanika Chopjitt, Surapon Wiangnon, Sam Li Sheng Chen, Amy Ming Fang Yen, Tony Hsiu Hsi Chen

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4 Citations (Scopus)

Abstract

Background: Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim of this study was to investigate whether the risk of stomach cancer from XRCC1 gene polymorphisms was modified by environmental factors in the Thai population. Methods: Hospital-based matched case-control study data were collected from 101 new stomach cancer cases and 202 controls, which were recruited from2002 to 2006 and were matched for gender and age. Genotype analysis was performed using real-time PCR-HRM. The data were analysed by the chi-square test and conditional logistic regression. Results: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95%CI, 1.30-10.72) compared with Gln/Gln homozygosity. The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype. There were, however, no additive effects on the risk of stomach cancer between variants of the XRCC1gene and smoking,alcohol or pork oil consumption. Conclusions: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.

Original languageEnglish
Article number680
JournalBMC Cancer
Volume17
Issue number1
DOIs
Publication statusPublished - Oct 11 2017

Fingerprint

Cancer Care Facilities
DNA Repair
Stomach Neoplasms
Case-Control Studies
Genes
X-Rays
Plant Oils
Salts
Genotype
Homozygote
Chi-Square Distribution
Population
Real-Time Polymerase Chain Reaction
Oils
Logistic Models
Smoking
Alcohols

Keywords

  • Salt intake
  • Stomach cancer
  • Vegetable oil
  • XRCC1 gene

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Putthanachote, N., Promthet, S., Hurst, C., Suwanrungruang, K., Chopjitt, P., Wiangnon, S., ... Chen, T. H. H. (2017). The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: A hospital-based matched case-control study. BMC Cancer, 17(1), [680]. https://doi.org/10.1186/s12885-017-3675-9

The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer : A hospital-based matched case-control study. / Putthanachote, Nuntiput; Promthet, Supannee; Hurst, Cameron; Suwanrungruang, Krittika; Chopjitt, Peechanika; Wiangnon, Surapon; Chen, Sam Li Sheng; Yen, Amy Ming Fang; Chen, Tony Hsiu Hsi.

In: BMC Cancer, Vol. 17, No. 1, 680, 11.10.2017.

Research output: Contribution to journalArticle

Putthanachote, N, Promthet, S, Hurst, C, Suwanrungruang, K, Chopjitt, P, Wiangnon, S, Chen, SLS, Yen, AMF & Chen, THH 2017, 'The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: A hospital-based matched case-control study', BMC Cancer, vol. 17, no. 1, 680. https://doi.org/10.1186/s12885-017-3675-9
Putthanachote, Nuntiput ; Promthet, Supannee ; Hurst, Cameron ; Suwanrungruang, Krittika ; Chopjitt, Peechanika ; Wiangnon, Surapon ; Chen, Sam Li Sheng ; Yen, Amy Ming Fang ; Chen, Tony Hsiu Hsi. / The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer : A hospital-based matched case-control study. In: BMC Cancer. 2017 ; Vol. 17, No. 1.
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abstract = "Background: Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim of this study was to investigate whether the risk of stomach cancer from XRCC1 gene polymorphisms was modified by environmental factors in the Thai population. Methods: Hospital-based matched case-control study data were collected from 101 new stomach cancer cases and 202 controls, which were recruited from2002 to 2006 and were matched for gender and age. Genotype analysis was performed using real-time PCR-HRM. The data were analysed by the chi-square test and conditional logistic regression. Results: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95{\%}CI, 1.30-10.72) compared with Gln/Gln homozygosity. The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype. There were, however, no additive effects on the risk of stomach cancer between variants of the XRCC1gene and smoking,alcohol or pork oil consumption. Conclusions: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.",
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author = "Nuntiput Putthanachote and Supannee Promthet and Cameron Hurst and Krittika Suwanrungruang and Peechanika Chopjitt and Surapon Wiangnon and Chen, {Sam Li Sheng} and Yen, {Amy Ming Fang} and Chen, {Tony Hsiu Hsi}",
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AU - Hurst, Cameron

AU - Suwanrungruang, Krittika

AU - Chopjitt, Peechanika

AU - Wiangnon, Surapon

AU - Chen, Sam Li Sheng

AU - Yen, Amy Ming Fang

AU - Chen, Tony Hsiu Hsi

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N2 - Background: Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim of this study was to investigate whether the risk of stomach cancer from XRCC1 gene polymorphisms was modified by environmental factors in the Thai population. Methods: Hospital-based matched case-control study data were collected from 101 new stomach cancer cases and 202 controls, which were recruited from2002 to 2006 and were matched for gender and age. Genotype analysis was performed using real-time PCR-HRM. The data were analysed by the chi-square test and conditional logistic regression. Results: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95%CI, 1.30-10.72) compared with Gln/Gln homozygosity. The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype. There were, however, no additive effects on the risk of stomach cancer between variants of the XRCC1gene and smoking,alcohol or pork oil consumption. Conclusions: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.

AB - Background: Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim of this study was to investigate whether the risk of stomach cancer from XRCC1 gene polymorphisms was modified by environmental factors in the Thai population. Methods: Hospital-based matched case-control study data were collected from 101 new stomach cancer cases and 202 controls, which were recruited from2002 to 2006 and were matched for gender and age. Genotype analysis was performed using real-time PCR-HRM. The data were analysed by the chi-square test and conditional logistic regression. Results: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95%CI, 1.30-10.72) compared with Gln/Gln homozygosity. The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype. There were, however, no additive effects on the risk of stomach cancer between variants of the XRCC1gene and smoking,alcohol or pork oil consumption. Conclusions: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.

KW - Salt intake

KW - Stomach cancer

KW - Vegetable oil

KW - XRCC1 gene

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