The value of pyrans as anticancer scaffolds in medicinal chemistry

Dinesh Kumar, Pooja Sharma, Harmanpreet Singh, Kunal Nepali, Girish Kumar Gupta, Subheet Kumar Jain, Fidele Ntie-Kang

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Pyran is an oxygen-containing heterocyclic moiety, which exhibits an array of pharmacological properties. Pyran is also one of the important structural subunits found widely in natural products, e.g. coumarins, benzopyrans, sugars, flavonoids, xanthones, etc. The diverse anticancer capabilities of pyrans have been additionally evidenced by the fact that this heterocycle has recently been a focal point for researchers worldwide. This review provides a summary of pyran-based anticancer compounds, with emphasis on the past 10 years. It focuses on advancements in the field of naturally occurring pyrans as anticancer agents. The discussion also includes structure-activity relationships, along with the structures of the most promising molecules, their biological activities against several human cancer cell lines, as well as mechanistic insights discovered through the pharmacological evaluation and molecular modeling of pyran-based molecules. The promising activities revealed by these pyran-based scaffolds undoubtedly place them at the forefront for the discovery of prospective drug candidates. Thus, they could therefore be of great interest to researchers working on the synthesis of antitumour drug candidates.

Original languageEnglish
Pages (from-to)36977-36999
Number of pages23
JournalRSC Advances
Volume7
Issue number59
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Kumar, D., Sharma, P., Singh, H., Nepali, K., Gupta, G. K., Jain, S. K., & Ntie-Kang, F. (2017). The value of pyrans as anticancer scaffolds in medicinal chemistry. RSC Advances, 7(59), 36977-36999. https://doi.org/10.1039/c7ra05441f