The value of plasma levels of tumor necrosis factor-α and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure

Jun Pin Pan, Tu Ying Liu, Shu Chiung Chiang, Yung-Kuo Lin, Chia Yea Chou, Wan Leong Chan, Shiau Tung Lai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background. High plasma levels of pro-inflammatory cytokines play an important role in the pathophysiology of congestive heart failure (CHF). Therefore, we conducted a case-control study to determine the correlations between plasma levels of cytokines, i.e., tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, and the severity and mortality in patients with CHF. Methods. One-hundred and 18 cases (62 ± 15 years old) were classified into 3 groups: group 1 comprised 44 control cases with normal coronary arteriogram and left ventriculography and without valvular disorders or cardiomyopathy; group 2 comprised of 37 cases with mild CHF in New York Heart Association (NYHA) functional class (FC) II; group 3 had 37 cases with moderate/severe CHF in NYHA FC III or IV. Pre-catheterization plasma levels of TNF-α. and IL-6 along with clinical and hemodynamic variables and follow-up data of cardiac death were assessed. Results. Patients of group 3 had smaller body mass index, lower systolic and diastolic blood pressures, faster heart rates, higher left ventricular end-diastolic pressure and lowered triglyceride levels than the patients of groups 1 and 2. The plasma levels of TNF-α. and IL-6 increased significantly in patients of group 3 in comparison with patients of groups 1 and 2 (both p <0.001). Over the following 1.5 years, 13 patients died. Univariate analysis identified the following variables to be associated with poor prognosis: NYHA FC (p <0.001), plasma TNF-α (p = 0.013), plasma IL-6 (p <0.001), systolic bloodpressure (p = 0.001), heart rate (p = 0.045) and left ventricular end-diastolic pressure (p = 0.021). Multivariate Cox regression analysis identified the independent predictors of cardiac death as FC (p = 0.007) and plasma IL-6 (p = 0.021). Conclusions. Our findings indicate that the plasma levels of IL-6 and TNF-α and especially the former, is a useful marker to correlate the progression of severity and late cardiac death in patients with CHF.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalJournal of the Chinese Medical Association
Volume67
Issue number5
Publication statusPublished - May 2004
Externally publishedYes

Fingerprint

Interleukin-6
Heart Failure
Tumor Necrosis Factor-alpha
Blood Pressure
Heart Rate
Cytokines
Cardiomyopathies
Catheterization
Case-Control Studies
Triglycerides
Body Mass Index
Hemodynamics
Regression Analysis
Mortality

Keywords

  • Congestive heart failure
  • Cytokines
  • Interleukin-6
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The value of plasma levels of tumor necrosis factor-α and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure. / Pan, Jun Pin; Liu, Tu Ying; Chiang, Shu Chiung; Lin, Yung-Kuo; Chou, Chia Yea; Chan, Wan Leong; Lai, Shiau Tung.

In: Journal of the Chinese Medical Association, Vol. 67, No. 5, 05.2004, p. 222-228.

Research output: Contribution to journalArticle

Pan, Jun Pin ; Liu, Tu Ying ; Chiang, Shu Chiung ; Lin, Yung-Kuo ; Chou, Chia Yea ; Chan, Wan Leong ; Lai, Shiau Tung. / The value of plasma levels of tumor necrosis factor-α and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure. In: Journal of the Chinese Medical Association. 2004 ; Vol. 67, No. 5. pp. 222-228.
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abstract = "Background. High plasma levels of pro-inflammatory cytokines play an important role in the pathophysiology of congestive heart failure (CHF). Therefore, we conducted a case-control study to determine the correlations between plasma levels of cytokines, i.e., tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, and the severity and mortality in patients with CHF. Methods. One-hundred and 18 cases (62 ± 15 years old) were classified into 3 groups: group 1 comprised 44 control cases with normal coronary arteriogram and left ventriculography and without valvular disorders or cardiomyopathy; group 2 comprised of 37 cases with mild CHF in New York Heart Association (NYHA) functional class (FC) II; group 3 had 37 cases with moderate/severe CHF in NYHA FC III or IV. Pre-catheterization plasma levels of TNF-α. and IL-6 along with clinical and hemodynamic variables and follow-up data of cardiac death were assessed. Results. Patients of group 3 had smaller body mass index, lower systolic and diastolic blood pressures, faster heart rates, higher left ventricular end-diastolic pressure and lowered triglyceride levels than the patients of groups 1 and 2. The plasma levels of TNF-α. and IL-6 increased significantly in patients of group 3 in comparison with patients of groups 1 and 2 (both p <0.001). Over the following 1.5 years, 13 patients died. Univariate analysis identified the following variables to be associated with poor prognosis: NYHA FC (p <0.001), plasma TNF-α (p = 0.013), plasma IL-6 (p <0.001), systolic bloodpressure (p = 0.001), heart rate (p = 0.045) and left ventricular end-diastolic pressure (p = 0.021). Multivariate Cox regression analysis identified the independent predictors of cardiac death as FC (p = 0.007) and plasma IL-6 (p = 0.021). Conclusions. Our findings indicate that the plasma levels of IL-6 and TNF-α and especially the former, is a useful marker to correlate the progression of severity and late cardiac death in patients with CHF.",
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T1 - The value of plasma levels of tumor necrosis factor-α and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure

AU - Pan, Jun Pin

AU - Liu, Tu Ying

AU - Chiang, Shu Chiung

AU - Lin, Yung-Kuo

AU - Chou, Chia Yea

AU - Chan, Wan Leong

AU - Lai, Shiau Tung

PY - 2004/5

Y1 - 2004/5

N2 - Background. High plasma levels of pro-inflammatory cytokines play an important role in the pathophysiology of congestive heart failure (CHF). Therefore, we conducted a case-control study to determine the correlations between plasma levels of cytokines, i.e., tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, and the severity and mortality in patients with CHF. Methods. One-hundred and 18 cases (62 ± 15 years old) were classified into 3 groups: group 1 comprised 44 control cases with normal coronary arteriogram and left ventriculography and without valvular disorders or cardiomyopathy; group 2 comprised of 37 cases with mild CHF in New York Heart Association (NYHA) functional class (FC) II; group 3 had 37 cases with moderate/severe CHF in NYHA FC III or IV. Pre-catheterization plasma levels of TNF-α. and IL-6 along with clinical and hemodynamic variables and follow-up data of cardiac death were assessed. Results. Patients of group 3 had smaller body mass index, lower systolic and diastolic blood pressures, faster heart rates, higher left ventricular end-diastolic pressure and lowered triglyceride levels than the patients of groups 1 and 2. The plasma levels of TNF-α. and IL-6 increased significantly in patients of group 3 in comparison with patients of groups 1 and 2 (both p <0.001). Over the following 1.5 years, 13 patients died. Univariate analysis identified the following variables to be associated with poor prognosis: NYHA FC (p <0.001), plasma TNF-α (p = 0.013), plasma IL-6 (p <0.001), systolic bloodpressure (p = 0.001), heart rate (p = 0.045) and left ventricular end-diastolic pressure (p = 0.021). Multivariate Cox regression analysis identified the independent predictors of cardiac death as FC (p = 0.007) and plasma IL-6 (p = 0.021). Conclusions. Our findings indicate that the plasma levels of IL-6 and TNF-α and especially the former, is a useful marker to correlate the progression of severity and late cardiac death in patients with CHF.

AB - Background. High plasma levels of pro-inflammatory cytokines play an important role in the pathophysiology of congestive heart failure (CHF). Therefore, we conducted a case-control study to determine the correlations between plasma levels of cytokines, i.e., tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, and the severity and mortality in patients with CHF. Methods. One-hundred and 18 cases (62 ± 15 years old) were classified into 3 groups: group 1 comprised 44 control cases with normal coronary arteriogram and left ventriculography and without valvular disorders or cardiomyopathy; group 2 comprised of 37 cases with mild CHF in New York Heart Association (NYHA) functional class (FC) II; group 3 had 37 cases with moderate/severe CHF in NYHA FC III or IV. Pre-catheterization plasma levels of TNF-α. and IL-6 along with clinical and hemodynamic variables and follow-up data of cardiac death were assessed. Results. Patients of group 3 had smaller body mass index, lower systolic and diastolic blood pressures, faster heart rates, higher left ventricular end-diastolic pressure and lowered triglyceride levels than the patients of groups 1 and 2. The plasma levels of TNF-α. and IL-6 increased significantly in patients of group 3 in comparison with patients of groups 1 and 2 (both p <0.001). Over the following 1.5 years, 13 patients died. Univariate analysis identified the following variables to be associated with poor prognosis: NYHA FC (p <0.001), plasma TNF-α (p = 0.013), plasma IL-6 (p <0.001), systolic bloodpressure (p = 0.001), heart rate (p = 0.045) and left ventricular end-diastolic pressure (p = 0.021). Multivariate Cox regression analysis identified the independent predictors of cardiac death as FC (p = 0.007) and plasma IL-6 (p = 0.021). Conclusions. Our findings indicate that the plasma levels of IL-6 and TNF-α and especially the former, is a useful marker to correlate the progression of severity and late cardiac death in patients with CHF.

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