The value of MR T2* measurements in normal and osteoarthritic knee cartilage

effects of age, sex, and location

Ping Huei Tsai, Chin Chean Wong, Wing P. Chan, Tung Wu Lu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21–40 years, 41–60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. Results: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). Conclusion: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. Key Points: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.

Original languageEnglish
JournalEuropean Radiology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Cartilage
Knee
Thigh
Osteoarthritis
Weight-Bearing

Keywords

  • Cartilage
  • Diagnostic imaging
  • Knee
  • Magnetic resonance imaging (MRI)
  • Osteoarthritis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{872860a3fd894505a023f5d2771424df,
title = "The value of MR T2* measurements in normal and osteoarthritic knee cartilage: effects of age, sex, and location",
abstract = "Objectives: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21–40 years, 41–60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. Results: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). Conclusion: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. Key Points: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.",
keywords = "Cartilage, Diagnostic imaging, Knee, Magnetic resonance imaging (MRI), Osteoarthritis",
author = "Tsai, {Ping Huei} and Wong, {Chin Chean} and Chan, {Wing P.} and Lu, {Tung Wu}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00330-018-5826-z",
language = "English",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - The value of MR T2* measurements in normal and osteoarthritic knee cartilage

T2 - effects of age, sex, and location

AU - Tsai, Ping Huei

AU - Wong, Chin Chean

AU - Chan, Wing P.

AU - Lu, Tung Wu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21–40 years, 41–60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. Results: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). Conclusion: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. Key Points: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.

AB - Objectives: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21–40 years, 41–60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. Results: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). Conclusion: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. Key Points: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.

KW - Cartilage

KW - Diagnostic imaging

KW - Knee

KW - Magnetic resonance imaging (MRI)

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=85059661363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059661363&partnerID=8YFLogxK

U2 - 10.1007/s00330-018-5826-z

DO - 10.1007/s00330-018-5826-z

M3 - Article

JO - European Radiology

JF - European Radiology

SN - 0938-7994

ER -