The value of human growth hormone as an adjuvant for ovarian stimulation in a human in vitro fertilization program

Ming Yih Wu, Hsin Fu Chen, Hong Nerng Ho, Shee Uan Chen, Kuang Han Chao, Su Cheng Huang, Tzu Yao Lee, Yu Shih Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The purpose of this study was to evaluate whether the combined treatment of growth hormone (GH) and gonadotropins can improve ovulation stimulation in previously poor responders. Twelve patients who, had suboptimal responses in previous in vitro fertilization cycle were enrolled. They underwent 1 cycle with gonadotropin-releasing hormone analogue (GnRH-a) and gonadotropins and another cycle with GnRH-a, gonadotropins, and GH. Serum gonadotropins, insulin-like growth factor-1 (IGF-1), and sex steroids, including estradiol (E 2 ), progesterone (P 4 ), testosterone, and androstenedione were measured on Day 2 and during ovulation induction. The serum IGF-1 level was higher in the GH cycle. There were no significant differences in the levels of the serum luteinizing hormone, E 2 , P 4 , testosterone, and androstenedione between the 2 cycles, so was IGF-1, E 2 and P 4 in follicular fluid. Co-treatment with GH did not improve the ovarian response. However, the GH cycles had better performance in terms of the number of oocytes fertilized and the pregnancy rate.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalJournal of Obstetrics and Gynaecology Research
Volume22
Issue number5
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Human Growth Hormone
Ovulation Induction
Fertilization in Vitro
Growth Hormone
Gonadotropins
Somatomedins
Androstenedione
Gonadotropin-Releasing Hormone
Testosterone
Serum
Follicular Fluid
Pregnancy Rate
Luteinizing Hormone
Ovulation
Oocytes
Progesterone
Estradiol
Steroids
Therapeutics
N,N-diethyl-2-(1-pyridyl)ethylamine

Keywords

  • Gonadotropin
  • Human growth hormone
  • In vitro fertilization
  • Insulin-like growth factor-1
  • Ovulation stimulation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

The value of human growth hormone as an adjuvant for ovarian stimulation in a human in vitro fertilization program. / Wu, Ming Yih; Chen, Hsin Fu; Ho, Hong Nerng; Chen, Shee Uan; Chao, Kuang Han; Huang, Su Cheng; Lee, Tzu Yao; Yang, Yu Shih.

In: Journal of Obstetrics and Gynaecology Research, Vol. 22, No. 5, 01.01.1996, p. 443-450.

Research output: Contribution to journalArticle

Wu, Ming Yih ; Chen, Hsin Fu ; Ho, Hong Nerng ; Chen, Shee Uan ; Chao, Kuang Han ; Huang, Su Cheng ; Lee, Tzu Yao ; Yang, Yu Shih. / The value of human growth hormone as an adjuvant for ovarian stimulation in a human in vitro fertilization program. In: Journal of Obstetrics and Gynaecology Research. 1996 ; Vol. 22, No. 5. pp. 443-450.
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