Abstract
Autogenous bone grafting is still the gold standard for use in bone defects in orthopedic, plastic, and craniofacial surgeries. However, some patients are unable to provide sufficient quantity of bone and the high postoperative morbidity limits its clinical use. Currently, various bone substitutes are available for clinical applications, including calcium phosphate and biodegradable polyester. But hydroxyapatite is considered nondegradable and the degradation rate of biodegradable polyester is too fast, therefore both these biomaterials are hardly used clinically. To resolve this problem, we fabricated a biodegradable porous bone substitute by merging poly(L-lactic-co-glycolic acid) (PLGA) and β-tricalcium phosphate (TCP), such that the new bone substitute could provide the advantages of both the materials. The New Zealand white rabbit femur defect model was used to assess the biocompatibility and degree of osteoconduction of this new bone substitute. There was no inflammatory reaction at the PLGA/TCP grafting site based on our macroscopic observations. Three months after grafting, the cavity and central portion of the created defect within the rabbit femur was filled with newly formed bone. Furthermore, the new ingrown bone tissues readily matured to secondary bone with Haversian systems similar to the surrounding cancellous bone. We conclude that the newly fabricated PLGA/TCP shows both excellent biocompatibility and effective osteoconduction.
| Original language | English |
|---|---|
| Pages (from-to) | 263-270 |
| Number of pages | 8 |
| Journal | Biomedical Engineering - Applications, Basis and Communications |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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Keywords
- Animal study
- Bone graft material
- Bone regeneration
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Biomedical Engineering
Cite this
The use of poly(L-lactic-co-glycolic acid)/tricalcium phosphate as a bone substitute in rabbit femur defects model. / Kuo, Yi J.; Liao, Chun J.; Rau, Gary; Chen, Chia Hsien; Yang, Chih Hong; Tsuang, Yang Hwei.
In: Biomedical Engineering - Applications, Basis and Communications, Vol. 22, No. 4, 08.2010, p. 263-270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of poly(L-lactic-co-glycolic acid)/tricalcium phosphate as a bone substitute in rabbit femur defects model
AU - Kuo, Yi J.
AU - Liao, Chun J.
AU - Rau, Gary
AU - Chen, Chia Hsien
AU - Yang, Chih Hong
AU - Tsuang, Yang Hwei
PY - 2010/8
Y1 - 2010/8
N2 - Autogenous bone grafting is still the gold standard for use in bone defects in orthopedic, plastic, and craniofacial surgeries. However, some patients are unable to provide sufficient quantity of bone and the high postoperative morbidity limits its clinical use. Currently, various bone substitutes are available for clinical applications, including calcium phosphate and biodegradable polyester. But hydroxyapatite is considered nondegradable and the degradation rate of biodegradable polyester is too fast, therefore both these biomaterials are hardly used clinically. To resolve this problem, we fabricated a biodegradable porous bone substitute by merging poly(L-lactic-co-glycolic acid) (PLGA) and β-tricalcium phosphate (TCP), such that the new bone substitute could provide the advantages of both the materials. The New Zealand white rabbit femur defect model was used to assess the biocompatibility and degree of osteoconduction of this new bone substitute. There was no inflammatory reaction at the PLGA/TCP grafting site based on our macroscopic observations. Three months after grafting, the cavity and central portion of the created defect within the rabbit femur was filled with newly formed bone. Furthermore, the new ingrown bone tissues readily matured to secondary bone with Haversian systems similar to the surrounding cancellous bone. We conclude that the newly fabricated PLGA/TCP shows both excellent biocompatibility and effective osteoconduction.
AB - Autogenous bone grafting is still the gold standard for use in bone defects in orthopedic, plastic, and craniofacial surgeries. However, some patients are unable to provide sufficient quantity of bone and the high postoperative morbidity limits its clinical use. Currently, various bone substitutes are available for clinical applications, including calcium phosphate and biodegradable polyester. But hydroxyapatite is considered nondegradable and the degradation rate of biodegradable polyester is too fast, therefore both these biomaterials are hardly used clinically. To resolve this problem, we fabricated a biodegradable porous bone substitute by merging poly(L-lactic-co-glycolic acid) (PLGA) and β-tricalcium phosphate (TCP), such that the new bone substitute could provide the advantages of both the materials. The New Zealand white rabbit femur defect model was used to assess the biocompatibility and degree of osteoconduction of this new bone substitute. There was no inflammatory reaction at the PLGA/TCP grafting site based on our macroscopic observations. Three months after grafting, the cavity and central portion of the created defect within the rabbit femur was filled with newly formed bone. Furthermore, the new ingrown bone tissues readily matured to secondary bone with Haversian systems similar to the surrounding cancellous bone. We conclude that the newly fabricated PLGA/TCP shows both excellent biocompatibility and effective osteoconduction.
KW - Animal study
KW - Bone graft material
KW - Bone regeneration
UR - http://www.scopus.com/inward/record.url?scp=77955324842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955324842&partnerID=8YFLogxK
U2 - 10.4015/S1016237210002092
DO - 10.4015/S1016237210002092
M3 - Article
VL - 22
SP - 263
EP - 270
JO - Journal of Chinese Corrosion Engineering
JF - Journal of Chinese Corrosion Engineering
SN - 1016-2372
IS - 4
ER -