The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions

Yang Hao Yu, Wu Huei Hsu, Nan Yung Hsu, Tze Yi Lin, Te Chun Hsia, Shung Shung Sun, Chia Hung Kao

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: This study examines the usefulness of thallium-201 single photon emission computed tomography (201Tl SPECT) in differentiating pulmonary malignancies from benign lesions by using dual phase 201Tl scintigraphy. Methods: One hundred and six patients with thoracic lesions and confirmed diagnoses were assessed by 201Tl chest SPECT examinations; of these 106 enrolled thoracic lesions, 59 were malignancies and 47 were benign lesions. Dual phase 201Tl SPECT was performed with an early image acquired at 10-20 min and a delayed image at 2-3 h after intravenous injection of 2-3 mCi of 201Tl. The results of 201Tl SPECT images were classified as either malignant or benign lesions by visual interpretation: the lesion was interpreted as positive for malignancy if the uptake of 201Tl in the lung lesion in the delayed phase was increased or persistent as compared with that in the early phase image; otherwise, it was considered as a benign lesion. Simultaneously, the traditional method of retention index (RI) was also calculated to help in the differential diagnosis of pulmonary lesions. Then, both methods of dual phase 201Tl SPECT, visual reading and traditional RI, were compared to differentiate pulmonary malignancies from benign lesions. Results: Analyzing the image results, we found that dual phase 201Tl SPECT could differentiate pulmonary malignancies from benign lesions with a sensitivity of 83%, a specificity of 91% and an accuracy of 87%. Moreover, by using the traditional RI method of 201Tl SPECT, it could differentiate pulmonary malignancy from benign lesions with a sensitivity of 79.3%, a specificity of 80.8% and an accuracy of 80%. Conclusions: We conclude that using dual phase 201Tl SPECT with visual interpretation is a simpler and potentially more effective method for differentiating pulmonary malignancies from benign lesions, with results compatible with the traditional RI method of 201 Tl SPECT.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume34
Issue number8
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Single-Photon Emission-Computed Tomography
Lung
Neoplasms
Thorax
Thallium
Intravenous Injections
Radionuclide Imaging
Reading
Differential Diagnosis

Keywords

  • Lung cancer
  • Pulmonary lesions
  • Retention index
  • SPECT
  • Thallium-201

ASJC Scopus subject areas

  • Oncology

Cite this

Yu, Y. H., Hsu, W. H., Hsu, N. Y., Lin, T. Y., Hsia, T. C., Sun, S. S., & Kao, C. H. (2004). The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions. Japanese Journal of Clinical Oncology, 34(8), 445-451. https://doi.org/10.1093/jjco/hyh080

The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions. / Yu, Yang Hao; Hsu, Wu Huei; Hsu, Nan Yung; Lin, Tze Yi; Hsia, Te Chun; Sun, Shung Shung; Kao, Chia Hung.

In: Japanese Journal of Clinical Oncology, Vol. 34, No. 8, 08.2004, p. 445-451.

Research output: Contribution to journalArticle

Yu, Yang Hao ; Hsu, Wu Huei ; Hsu, Nan Yung ; Lin, Tze Yi ; Hsia, Te Chun ; Sun, Shung Shung ; Kao, Chia Hung. / The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions. In: Japanese Journal of Clinical Oncology. 2004 ; Vol. 34, No. 8. pp. 445-451.
@article{98c237178aef478c95d93f753ebc6252,
title = "The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions",
abstract = "Background: This study examines the usefulness of thallium-201 single photon emission computed tomography (201Tl SPECT) in differentiating pulmonary malignancies from benign lesions by using dual phase 201Tl scintigraphy. Methods: One hundred and six patients with thoracic lesions and confirmed diagnoses were assessed by 201Tl chest SPECT examinations; of these 106 enrolled thoracic lesions, 59 were malignancies and 47 were benign lesions. Dual phase 201Tl SPECT was performed with an early image acquired at 10-20 min and a delayed image at 2-3 h after intravenous injection of 2-3 mCi of 201Tl. The results of 201Tl SPECT images were classified as either malignant or benign lesions by visual interpretation: the lesion was interpreted as positive for malignancy if the uptake of 201Tl in the lung lesion in the delayed phase was increased or persistent as compared with that in the early phase image; otherwise, it was considered as a benign lesion. Simultaneously, the traditional method of retention index (RI) was also calculated to help in the differential diagnosis of pulmonary lesions. Then, both methods of dual phase 201Tl SPECT, visual reading and traditional RI, were compared to differentiate pulmonary malignancies from benign lesions. Results: Analyzing the image results, we found that dual phase 201Tl SPECT could differentiate pulmonary malignancies from benign lesions with a sensitivity of 83{\%}, a specificity of 91{\%} and an accuracy of 87{\%}. Moreover, by using the traditional RI method of 201Tl SPECT, it could differentiate pulmonary malignancy from benign lesions with a sensitivity of 79.3{\%}, a specificity of 80.8{\%} and an accuracy of 80{\%}. Conclusions: We conclude that using dual phase 201Tl SPECT with visual interpretation is a simpler and potentially more effective method for differentiating pulmonary malignancies from benign lesions, with results compatible with the traditional RI method of 201 Tl SPECT.",
keywords = "Lung cancer, Pulmonary lesions, Retention index, SPECT, Thallium-201",
author = "Yu, {Yang Hao} and Hsu, {Wu Huei} and Hsu, {Nan Yung} and Lin, {Tze Yi} and Hsia, {Te Chun} and Sun, {Shung Shung} and Kao, {Chia Hung}",
year = "2004",
month = "8",
doi = "10.1093/jjco/hyh080",
language = "English",
volume = "34",
pages = "445--451",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - The use of dual phase 201Tl SPECT for differentiating pulmonary malignancies from benign lesions

AU - Yu, Yang Hao

AU - Hsu, Wu Huei

AU - Hsu, Nan Yung

AU - Lin, Tze Yi

AU - Hsia, Te Chun

AU - Sun, Shung Shung

AU - Kao, Chia Hung

PY - 2004/8

Y1 - 2004/8

N2 - Background: This study examines the usefulness of thallium-201 single photon emission computed tomography (201Tl SPECT) in differentiating pulmonary malignancies from benign lesions by using dual phase 201Tl scintigraphy. Methods: One hundred and six patients with thoracic lesions and confirmed diagnoses were assessed by 201Tl chest SPECT examinations; of these 106 enrolled thoracic lesions, 59 were malignancies and 47 were benign lesions. Dual phase 201Tl SPECT was performed with an early image acquired at 10-20 min and a delayed image at 2-3 h after intravenous injection of 2-3 mCi of 201Tl. The results of 201Tl SPECT images were classified as either malignant or benign lesions by visual interpretation: the lesion was interpreted as positive for malignancy if the uptake of 201Tl in the lung lesion in the delayed phase was increased or persistent as compared with that in the early phase image; otherwise, it was considered as a benign lesion. Simultaneously, the traditional method of retention index (RI) was also calculated to help in the differential diagnosis of pulmonary lesions. Then, both methods of dual phase 201Tl SPECT, visual reading and traditional RI, were compared to differentiate pulmonary malignancies from benign lesions. Results: Analyzing the image results, we found that dual phase 201Tl SPECT could differentiate pulmonary malignancies from benign lesions with a sensitivity of 83%, a specificity of 91% and an accuracy of 87%. Moreover, by using the traditional RI method of 201Tl SPECT, it could differentiate pulmonary malignancy from benign lesions with a sensitivity of 79.3%, a specificity of 80.8% and an accuracy of 80%. Conclusions: We conclude that using dual phase 201Tl SPECT with visual interpretation is a simpler and potentially more effective method for differentiating pulmonary malignancies from benign lesions, with results compatible with the traditional RI method of 201 Tl SPECT.

AB - Background: This study examines the usefulness of thallium-201 single photon emission computed tomography (201Tl SPECT) in differentiating pulmonary malignancies from benign lesions by using dual phase 201Tl scintigraphy. Methods: One hundred and six patients with thoracic lesions and confirmed diagnoses were assessed by 201Tl chest SPECT examinations; of these 106 enrolled thoracic lesions, 59 were malignancies and 47 were benign lesions. Dual phase 201Tl SPECT was performed with an early image acquired at 10-20 min and a delayed image at 2-3 h after intravenous injection of 2-3 mCi of 201Tl. The results of 201Tl SPECT images were classified as either malignant or benign lesions by visual interpretation: the lesion was interpreted as positive for malignancy if the uptake of 201Tl in the lung lesion in the delayed phase was increased or persistent as compared with that in the early phase image; otherwise, it was considered as a benign lesion. Simultaneously, the traditional method of retention index (RI) was also calculated to help in the differential diagnosis of pulmonary lesions. Then, both methods of dual phase 201Tl SPECT, visual reading and traditional RI, were compared to differentiate pulmonary malignancies from benign lesions. Results: Analyzing the image results, we found that dual phase 201Tl SPECT could differentiate pulmonary malignancies from benign lesions with a sensitivity of 83%, a specificity of 91% and an accuracy of 87%. Moreover, by using the traditional RI method of 201Tl SPECT, it could differentiate pulmonary malignancy from benign lesions with a sensitivity of 79.3%, a specificity of 80.8% and an accuracy of 80%. Conclusions: We conclude that using dual phase 201Tl SPECT with visual interpretation is a simpler and potentially more effective method for differentiating pulmonary malignancies from benign lesions, with results compatible with the traditional RI method of 201 Tl SPECT.

KW - Lung cancer

KW - Pulmonary lesions

KW - Retention index

KW - SPECT

KW - Thallium-201

UR - http://www.scopus.com/inward/record.url?scp=7944221824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7944221824&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyh080

DO - 10.1093/jjco/hyh080

M3 - Article

VL - 34

SP - 445

EP - 451

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 8

ER -