The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal

Marcela Rosas, Luke C. Davies, Peter J. Giles, Chia Te Liao, Bashar Kharfan, Timothy C. Stone, Valerie B. O'Donnell, Donald J. Fraser, Simon A. Jones, Philip R. Taylor

Research output: Contribution to journalArticlepeer-review

198 Citations (Scopus)

Abstract

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalScience
Volume344
Issue number6184
DOIs
Publication statusPublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • General

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