The Taipei adolescent twin/sibling family study II: Depression, insulin resistance, and hormonal factors

Shu Yu Kuo, Pi Hua Liu, Lee Ming Chuang, Wei J. Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalTwin Research and Human Genetics
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

R Factors
Insulin Resistance
Siblings
Depression
Psychology
Parents
Adolescent Development
Metabolome
DNA
Glucose Tolerance Test
Leptin
Self Report
Longitudinal Studies
Hydrocortisone
Body Mass Index
Interviews
Insulin
Blood Pressure
Phenotype
Lipids

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

The Taipei adolescent twin/sibling family study II : Depression, insulin resistance, and hormonal factors. / Kuo, Shu Yu; Liu, Pi Hua; Chuang, Lee Ming; Chen, Wei J.

In: Twin Research and Human Genetics, Vol. 9, No. 6, 12.2006, p. 895-898.

Research output: Contribution to journalArticle

@article{894eec7b889d418abcb675f842079b95,
title = "The Taipei adolescent twin/sibling family study II: Depression, insulin resistance, and hormonal factors",
abstract = "In this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.",
author = "Kuo, {Shu Yu} and Liu, {Pi Hua} and Chuang, {Lee Ming} and Chen, {Wei J.}",
year = "2006",
month = "12",
doi = "10.1375/183242706779462840",
language = "English",
volume = "9",
pages = "895--898",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",
number = "6",

}

TY - JOUR

T1 - The Taipei adolescent twin/sibling family study II

T2 - Depression, insulin resistance, and hormonal factors

AU - Kuo, Shu Yu

AU - Liu, Pi Hua

AU - Chuang, Lee Ming

AU - Chen, Wei J.

PY - 2006/12

Y1 - 2006/12

N2 - In this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.

AB - In this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.

UR - http://www.scopus.com/inward/record.url?scp=33846205105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846205105&partnerID=8YFLogxK

U2 - 10.1375/183242706779462840

DO - 10.1375/183242706779462840

M3 - Article

C2 - 17254427

AN - SCOPUS:33846205105

VL - 9

SP - 895

EP - 898

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 6

ER -