Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.
Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.
Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.
Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology