The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho, Hao Ching Wang, Tzu Ping Ko, Yuan Chih Chang, Andrew H J Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)


Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.

Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.

Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.

Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.

Original languageEnglish
Pages (from-to)27046-27054
Number of pages9
JournalJournal of Biological Chemistry
Issue number39
Publication statusPublished - Sep 26 2014


ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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