The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho, Hao Ching Wang, Tzu Ping Ko, Yuan Chih Chang, Andrew H J Wang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.

Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.

Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.

Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.

Original languageEnglish
Pages (from-to)27046-27054
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number39
DOIs
Publication statusPublished - Sep 26 2014

Fingerprint

Bacteriophage T4
Bacteriophages
Histones
DNA
Proteins
DNA-Binding Proteins
Gene Silencing
Protein Binding
Bacteria
Genes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS. / Ho, Chun Han; Wang, Hao Ching; Ko, Tzu Ping; Chang, Yuan Chih; Wang, Andrew H J.

In: Journal of Biological Chemistry, Vol. 289, No. 39, 26.09.2014, p. 27046-27054.

Research output: Contribution to journalArticle

Ho, Chun Han ; Wang, Hao Ching ; Ko, Tzu Ping ; Chang, Yuan Chih ; Wang, Andrew H J. / The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 39. pp. 27046-27054.
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