THE SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS: Substituted at Residue Positions 27 and 31

James Blake, Liang‐Fu ‐F Tseng, Wen‐Chang ‐C Chang, Choh Hao Li

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Four analogs of human β‐endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27‐phenylalanine, 31‐glycine]‐βh‐endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalInternational Journal of Peptide and Protein Research
Volume11
Issue number5
DOIs
Publication statusPublished - Jan 1 1978
Externally publishedYes

Keywords

  • opiate activity
  • peptide synthesis
  • β‐endorphin

ASJC Scopus subject areas

  • Biochemistry

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