The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang; C. C. Chen; S. Y. Lee; L. H. Shen; H. E. Wang

doi:10.1016/j.apradiso.2009.02.039

The synthesis and characterization of [¹²⁴I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang, C. C. Chen, S. Y. Lee, L. H. Shen, H. E. Wang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

6-[¹²⁴I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([¹²⁴I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [¹²⁴I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.

Original language	English
Pages (from-to)	1397-1400
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	67
Issue number	7-8
DOIs	https://doi.org/10.1016/j.apradiso.2009.02.039
Publication status	Published - Jul 1 2009

Keywords

Beta-amyloid
IMPY
Positron emission tomography

ASJC Scopus subject areas

Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.apradiso.2009.02.039

Cite this

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title = "The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease",

abstract = "6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.",

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AU - Chang, Kang-Wei

AU - Chen, C. C.

AU - Lee, S. Y.

AU - Shen, L. H.

AU - Wang, H. E.

PY - 2009/7/1

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AB - 6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.

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