The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang, C. C. Chen, S. Y. Lee, L. H. Shen, H. E. Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.

Original languageEnglish
Pages (from-to)1397-1400
Number of pages4
JournalApplied Radiation and Isotopes
Volume67
Issue number7-8
DOIs
Publication statusPublished - Jul 1 2009

Fingerprint

radioactivity
brain
mice
positrons
hippocampus
probes
cortexes
synthesis
pyridines
tomography

Keywords

  • Beta-amyloid
  • IMPY
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiation

Cite this

The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease. / Chang, Kang-Wei; Chen, C. C.; Lee, S. Y.; Shen, L. H.; Wang, H. E.

In: Applied Radiation and Isotopes, Vol. 67, No. 7-8, 01.07.2009, p. 1397-1400.

Research output: Contribution to journalArticle

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