The Swedish two-county trial twenty years later: Updated mortality results and new insights from long-term follow-up

László Tabár, Bedrich Vitak, Hsiu Hsi Chen, Stephen W. Duffy, Ming Fang Yen, Ching Feng Chiang, Ulla Brith Krusemo, Tibor Tot, Robert A. Smith

Research output: Contribution to journalArticle

397 Citations (Scopus)

Abstract

The benefit of invitation to mammographic screening observed in this trial is maintained as a highly significant 32% reduction in breast cancer mortality. Mammographic screening for breast cancer continues to save lives after up to 20 years. Screening derives this benefit by improving the distribution of tumors diagnosed with respect to prognostic categories based on node status, size, and histology of tumors. There is potential for modern screening programs with shorter interscreening intervals to achieve even greater improvements in prognostic category and greater reductions in breast cancer mortality. Mammography can discriminate a subpopulation of high-risk cases, those displaying casting-type calcifications on the mammogram, among very small tumors, with fundamental implications for diagnosis and treatment.

Original languageEnglish
Pages (from-to)625-651
Number of pages27
JournalRadiologic Clinics of North America
Volume38
Issue number4
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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  • Cite this

    Tabár, L., Vitak, B., Chen, H. H., Duffy, S. W., Yen, M. F., Chiang, C. F., Krusemo, U. B., Tot, T., & Smith, R. A. (2000). The Swedish two-county trial twenty years later: Updated mortality results and new insights from long-term follow-up. Radiologic Clinics of North America, 38(4), 625-651.