The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects

W. S. Kuo, S. T. Ho, O. Y. Hu, C. H. Li, C. S. Hwing

Research output: Contribution to journalArticle

Abstract

Intravenous succinylcholine (SCh) is widely used as a muscle relaxant but it is often associated with adverse effects, including muscle fasciculations, postoperative myalgia, elevated serum potassium (K+) and creatine phosphokinase (CPK), etc. The present study was undertaken to evaluate the effects of pretreatment with Diphenylhydantoin (DPH) or d-Tubocurarine (d-TC) on SCh-induced adverse effects. 54 ASA I-II adult patients were randomly divided into 3 groups of 18 patients each. Four min before injection of SCh, group A received 1 ml of normal saline as a control group, group B DPH 2.5 mg kg-1 and group C d-TC 50 micrograms kg-1. Anesthesia was induced with thiopentone 3-4 mg kg-1 and then SCh was given to facilitate tracheal intubation. Anesthesia was maintained with isoflurane and nitrous oxide in oxygen. Muscle fasciculations, postoperative 24 hours myalgia, intubating conditions and levels of serum K+, CPK and DPH were recorded in every patient. All data were analyzed with Chi-Square and ANOVA tests. DPH and d-TC significantly decreased the incidence of fasciculations, whereas there were no differences regarding intubating condition, post-operative myalgia, and serum K+ among three groups. DPH concentration was 8.49 +/- 1.55 micrograms ml-1. Serum CPK was increased postoperatively in three groups. Pretreatment with DPH 2.5 mg kg-1 or d-TC 50 micrograms kg-1 effectively decreased SCh-induced fasciculations and did not affect intubating condition facilitated with SCh 1.5 mg kg-1. Nevertheless, these pretreatment did not improve postoperative myalgia and decrease serum CPK.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalActa Anaesthesiologica Sinica
Volume28
Issue number3
Publication statusPublished - Sep 1 1990
Externally publishedYes

Fingerprint

Tubocurarine
Succinylcholine
Phenytoin
Fasciculation
Myalgia
Creatine Kinase
Serum
Muscles
Anesthesia
Thiopental
Isoflurane
Nitrous Oxide
Chi-Square Distribution
Intubation
Analysis of Variance
Potassium
Oxygen
Control Groups
Injections
Incidence

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects. / Kuo, W. S.; Ho, S. T.; Hu, O. Y.; Li, C. H.; Hwing, C. S.

In: Acta Anaesthesiologica Sinica, Vol. 28, No. 3, 01.09.1990, p. 323-328.

Research output: Contribution to journalArticle

Kuo, W. S. ; Ho, S. T. ; Hu, O. Y. ; Li, C. H. ; Hwing, C. S. / The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects. In: Acta Anaesthesiologica Sinica. 1990 ; Vol. 28, No. 3. pp. 323-328.
@article{224601f83fe94d65a43529ff5011835f,
title = "The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects",
abstract = "Intravenous succinylcholine (SCh) is widely used as a muscle relaxant but it is often associated with adverse effects, including muscle fasciculations, postoperative myalgia, elevated serum potassium (K+) and creatine phosphokinase (CPK), etc. The present study was undertaken to evaluate the effects of pretreatment with Diphenylhydantoin (DPH) or d-Tubocurarine (d-TC) on SCh-induced adverse effects. 54 ASA I-II adult patients were randomly divided into 3 groups of 18 patients each. Four min before injection of SCh, group A received 1 ml of normal saline as a control group, group B DPH 2.5 mg kg-1 and group C d-TC 50 micrograms kg-1. Anesthesia was induced with thiopentone 3-4 mg kg-1 and then SCh was given to facilitate tracheal intubation. Anesthesia was maintained with isoflurane and nitrous oxide in oxygen. Muscle fasciculations, postoperative 24 hours myalgia, intubating conditions and levels of serum K+, CPK and DPH were recorded in every patient. All data were analyzed with Chi-Square and ANOVA tests. DPH and d-TC significantly decreased the incidence of fasciculations, whereas there were no differences regarding intubating condition, post-operative myalgia, and serum K+ among three groups. DPH concentration was 8.49 +/- 1.55 micrograms ml-1. Serum CPK was increased postoperatively in three groups. Pretreatment with DPH 2.5 mg kg-1 or d-TC 50 micrograms kg-1 effectively decreased SCh-induced fasciculations and did not affect intubating condition facilitated with SCh 1.5 mg kg-1. Nevertheless, these pretreatment did not improve postoperative myalgia and decrease serum CPK.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "Kuo, {W. S.} and Ho, {S. T.} and Hu, {O. Y.} and Li, {C. H.} and Hwing, {C. S.}",
year = "1990",
month = "9",
day = "1",
language = "English",
volume = "28",
pages = "323--328",
journal = "Asian Journal of Anesthesiology",
issn = "2468-824X",
publisher = "Elsevier Taiwan LLC",
number = "3",

}

TY - JOUR

T1 - The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects

AU - Kuo, W. S.

AU - Ho, S. T.

AU - Hu, O. Y.

AU - Li, C. H.

AU - Hwing, C. S.

PY - 1990/9/1

Y1 - 1990/9/1

N2 - Intravenous succinylcholine (SCh) is widely used as a muscle relaxant but it is often associated with adverse effects, including muscle fasciculations, postoperative myalgia, elevated serum potassium (K+) and creatine phosphokinase (CPK), etc. The present study was undertaken to evaluate the effects of pretreatment with Diphenylhydantoin (DPH) or d-Tubocurarine (d-TC) on SCh-induced adverse effects. 54 ASA I-II adult patients were randomly divided into 3 groups of 18 patients each. Four min before injection of SCh, group A received 1 ml of normal saline as a control group, group B DPH 2.5 mg kg-1 and group C d-TC 50 micrograms kg-1. Anesthesia was induced with thiopentone 3-4 mg kg-1 and then SCh was given to facilitate tracheal intubation. Anesthesia was maintained with isoflurane and nitrous oxide in oxygen. Muscle fasciculations, postoperative 24 hours myalgia, intubating conditions and levels of serum K+, CPK and DPH were recorded in every patient. All data were analyzed with Chi-Square and ANOVA tests. DPH and d-TC significantly decreased the incidence of fasciculations, whereas there were no differences regarding intubating condition, post-operative myalgia, and serum K+ among three groups. DPH concentration was 8.49 +/- 1.55 micrograms ml-1. Serum CPK was increased postoperatively in three groups. Pretreatment with DPH 2.5 mg kg-1 or d-TC 50 micrograms kg-1 effectively decreased SCh-induced fasciculations and did not affect intubating condition facilitated with SCh 1.5 mg kg-1. Nevertheless, these pretreatment did not improve postoperative myalgia and decrease serum CPK.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Intravenous succinylcholine (SCh) is widely used as a muscle relaxant but it is often associated with adverse effects, including muscle fasciculations, postoperative myalgia, elevated serum potassium (K+) and creatine phosphokinase (CPK), etc. The present study was undertaken to evaluate the effects of pretreatment with Diphenylhydantoin (DPH) or d-Tubocurarine (d-TC) on SCh-induced adverse effects. 54 ASA I-II adult patients were randomly divided into 3 groups of 18 patients each. Four min before injection of SCh, group A received 1 ml of normal saline as a control group, group B DPH 2.5 mg kg-1 and group C d-TC 50 micrograms kg-1. Anesthesia was induced with thiopentone 3-4 mg kg-1 and then SCh was given to facilitate tracheal intubation. Anesthesia was maintained with isoflurane and nitrous oxide in oxygen. Muscle fasciculations, postoperative 24 hours myalgia, intubating conditions and levels of serum K+, CPK and DPH were recorded in every patient. All data were analyzed with Chi-Square and ANOVA tests. DPH and d-TC significantly decreased the incidence of fasciculations, whereas there were no differences regarding intubating condition, post-operative myalgia, and serum K+ among three groups. DPH concentration was 8.49 +/- 1.55 micrograms ml-1. Serum CPK was increased postoperatively in three groups. Pretreatment with DPH 2.5 mg kg-1 or d-TC 50 micrograms kg-1 effectively decreased SCh-induced fasciculations and did not affect intubating condition facilitated with SCh 1.5 mg kg-1. Nevertheless, these pretreatment did not improve postoperative myalgia and decrease serum CPK.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0025490740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025490740&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 323

EP - 328

JO - Asian Journal of Anesthesiology

JF - Asian Journal of Anesthesiology

SN - 2468-824X

IS - 3

ER -