The study of directly compressible acetaminophen composition with fluidized-bed granulation

S. C. Chen, Y. C. Lee, T. D. Sokoloski, M. T. Sheu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of water and surfactants on the results of acetaminophen granulation in a fluidized-bed system was examined in this study. It showed that using enough amount of water was able to agglomerate acetaminophen powder into flowable granules. But tablets manufactured with such granules were not hard enough. The use of surfactants, sodium lauryl sulfate and pluronic F-68, had no significant effect on the size and distribution of particles at three concentrations (1, 3, and 5%) studied. Also, the dissolution of acetaminophen from tablets was not improved by the surfactants. However, using 5% of PVP as binder was able not only to obtain granules with well flowability, but also to increase the hardness of tablets to approximately 6 kg. An optimal acetaminophen formulation for direct compression should contain 5% PVP and a desired amount of disintegrant.

Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalChinese Pharmaceutical Journal
Volume47
Issue number3
Publication statusPublished - 1995

Keywords

  • acetaminophen
  • direct compression
  • PVP
  • surfactants

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

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