The study of directly compressible acetaminophen composition with fluidized-bed granulation

S. C. Chen, Y. C. Lee, T. D. Sokoloski, M. T. Sheu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of water and surfactants on the results of acetaminophen granulation in a fluidized-bed system was examined in this study. It showed that using enough amount of water was able to agglomerate acetaminophen powder into flowable granules. But tablets manufactured with such granules were not hard enough. The use of surfactants, sodium lauryl sulfate and pluronic F-68, had no significant effect on the size and distribution of particles at three concentrations (1, 3, and 5%) studied. Also, the dissolution of acetaminophen from tablets was not improved by the surfactants. However, using 5% of PVP as binder was able not only to obtain granules with well flowability, but also to increase the hardness of tablets to approximately 6 kg. An optimal acetaminophen formulation for direct compression should contain 5% PVP and a desired amount of disintegrant.

Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalChinese Pharmaceutical Journal
Volume47
Issue number3
Publication statusPublished - 1995

Fingerprint

Granulation
Acetaminophen
Fluidized beds
Surface active agents
Surface-Active Agents
Tablets
Chemical analysis
Sodium dodecyl sulfate
Poloxamer
Binders
Water
Hardness
Dissolution
Particle Size
Sodium Dodecyl Sulfate
Powders

Keywords

  • acetaminophen
  • direct compression
  • PVP
  • surfactants

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

Cite this

The study of directly compressible acetaminophen composition with fluidized-bed granulation. / Chen, S. C.; Lee, Y. C.; Sokoloski, T. D.; Sheu, M. T.

In: Chinese Pharmaceutical Journal, Vol. 47, No. 3, 1995, p. 221-233.

Research output: Contribution to journalArticle

@article{779878bee4ff4585a5fe4fcaf16509a6,
title = "The study of directly compressible acetaminophen composition with fluidized-bed granulation",
abstract = "The effect of water and surfactants on the results of acetaminophen granulation in a fluidized-bed system was examined in this study. It showed that using enough amount of water was able to agglomerate acetaminophen powder into flowable granules. But tablets manufactured with such granules were not hard enough. The use of surfactants, sodium lauryl sulfate and pluronic F-68, had no significant effect on the size and distribution of particles at three concentrations (1, 3, and 5{\%}) studied. Also, the dissolution of acetaminophen from tablets was not improved by the surfactants. However, using 5{\%} of PVP as binder was able not only to obtain granules with well flowability, but also to increase the hardness of tablets to approximately 6 kg. An optimal acetaminophen formulation for direct compression should contain 5{\%} PVP and a desired amount of disintegrant.",
keywords = "acetaminophen, direct compression, PVP, surfactants",
author = "Chen, {S. C.} and Lee, {Y. C.} and Sokoloski, {T. D.} and Sheu, {M. T.}",
year = "1995",
language = "English",
volume = "47",
pages = "221--233",
journal = "Taiwan Pharmaceutical Journal",
issn = "1016-1015",
publisher = "臺灣藥學會",
number = "3",

}

TY - JOUR

T1 - The study of directly compressible acetaminophen composition with fluidized-bed granulation

AU - Chen, S. C.

AU - Lee, Y. C.

AU - Sokoloski, T. D.

AU - Sheu, M. T.

PY - 1995

Y1 - 1995

N2 - The effect of water and surfactants on the results of acetaminophen granulation in a fluidized-bed system was examined in this study. It showed that using enough amount of water was able to agglomerate acetaminophen powder into flowable granules. But tablets manufactured with such granules were not hard enough. The use of surfactants, sodium lauryl sulfate and pluronic F-68, had no significant effect on the size and distribution of particles at three concentrations (1, 3, and 5%) studied. Also, the dissolution of acetaminophen from tablets was not improved by the surfactants. However, using 5% of PVP as binder was able not only to obtain granules with well flowability, but also to increase the hardness of tablets to approximately 6 kg. An optimal acetaminophen formulation for direct compression should contain 5% PVP and a desired amount of disintegrant.

AB - The effect of water and surfactants on the results of acetaminophen granulation in a fluidized-bed system was examined in this study. It showed that using enough amount of water was able to agglomerate acetaminophen powder into flowable granules. But tablets manufactured with such granules were not hard enough. The use of surfactants, sodium lauryl sulfate and pluronic F-68, had no significant effect on the size and distribution of particles at three concentrations (1, 3, and 5%) studied. Also, the dissolution of acetaminophen from tablets was not improved by the surfactants. However, using 5% of PVP as binder was able not only to obtain granules with well flowability, but also to increase the hardness of tablets to approximately 6 kg. An optimal acetaminophen formulation for direct compression should contain 5% PVP and a desired amount of disintegrant.

KW - acetaminophen

KW - direct compression

KW - PVP

KW - surfactants

UR - http://www.scopus.com/inward/record.url?scp=0029131052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029131052&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029131052

VL - 47

SP - 221

EP - 233

JO - Taiwan Pharmaceutical Journal

JF - Taiwan Pharmaceutical Journal

SN - 1016-1015

IS - 3

ER -