The Stathmokinetic Effect of Vincristine

Emil Frei, Jacqueline Whang, Robert B. Scoggins, Eugene J. Van Scott, David P. Rali, Max Ben

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A single dose of vincristine produced an increase in the mitotic index in the marrow, duodenum, and hair follicle of the rat and in the marrow, hair root, and malignant tumors of man. This increase in mitotic index resulted from “arrest” of cells in metaphase; other stages of mitosis were not increased, and post-metaphase stages decreased during vincristine effect. This mitotic “arrest” may be associated with cell death as evidenced by a quantitative decrease in cellularity of the rat bone marrow following administration of vincristine. For all the above tissues the increase in mitotic index was linear for at least the first 6 hours after vincristine and reached a peak at approximately 12 hours. There was an inverse correlation between the magnitude of the mitotic index increase and the generation time for the various tissues. This mitotic effect does not relate regularly to the toxic effect. For example, vincristine and vinblastine produced comparable marrow mitotic “arrest” in man, whereas leukopenia occurred regularly only with vinblastine. The interrelationships and implications of these findings are discussed.

Original languageEnglish
Pages (from-to)1918-1925
Number of pages8
JournalCancer Research
Volume24
Publication statusPublished - Dec 1 1964
Externally publishedYes

Fingerprint

Vincristine
Mitotic Index
Bone Marrow
Vinblastine
Metaphase
Hair Follicle
Poisons
Leukopenia
Duodenum
Mitosis
Hair
Cell Death
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Frei, E., Whang, J., Scoggins, R. B., Van Scott, E. J., Rali, D. P., & Ben, M. (1964). The Stathmokinetic Effect of Vincristine. Cancer Research, 24, 1918-1925.

The Stathmokinetic Effect of Vincristine. / Frei, Emil; Whang, Jacqueline; Scoggins, Robert B.; Van Scott, Eugene J.; Rali, David P.; Ben, Max.

In: Cancer Research, Vol. 24, 01.12.1964, p. 1918-1925.

Research output: Contribution to journalArticle

Frei, E, Whang, J, Scoggins, RB, Van Scott, EJ, Rali, DP & Ben, M 1964, 'The Stathmokinetic Effect of Vincristine', Cancer Research, vol. 24, pp. 1918-1925.
Frei E, Whang J, Scoggins RB, Van Scott EJ, Rali DP, Ben M. The Stathmokinetic Effect of Vincristine. Cancer Research. 1964 Dec 1;24:1918-1925.
Frei, Emil ; Whang, Jacqueline ; Scoggins, Robert B. ; Van Scott, Eugene J. ; Rali, David P. ; Ben, Max. / The Stathmokinetic Effect of Vincristine. In: Cancer Research. 1964 ; Vol. 24. pp. 1918-1925.
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