The stability of prostaglandin E1 ethylester

Lun Huei Lin, Hsiu O. Ho, Kuo Tung Chen, Han-Sun Chiang, Patrick Y K Wong, Ming Thau Sheu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to identify the conversion pathways of prostaglandin E1 (PGE1) ethylester during the stability tests in phosphate buffers (pH 7.4) and saline system at various temperature. A reversed phase HPLC system with a photodiode array detector was used to differentiate the UV spectrum of degradation species. By the comparison of UV spectrum of each chromatographic peak, it was confirmed that the dominate degradation pathway of PGE1 ethylester in phosphate buffer, as well as in 0.9 % NaCl solution, was the sequential formation of PGA1 ethylester and then PGB1 ethylester. A first-order reaction model could be used to describe the degradation of PGE1 ethylester via this route. The activation energy calculated by Arrhenius equation was 19.83 (2.11) and 21.67 (3.33) kcal/mole, respectively, for the reaction in these two media.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalChinese Pharmaceutical Journal
Volume50
Issue number2
Publication statusPublished - Apr 1998

Fingerprint

Alprostadil
Degradation
Buffers
Phosphates
Photodiodes
Activation energy
High Pressure Liquid Chromatography
Detectors
Temperature

Keywords

  • Degradation pathway
  • Prostaglandin E ethylester
  • Stability

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

Cite this

Lin, L. H., Ho, H. O., Chen, K. T., Chiang, H-S., Wong, P. Y. K., & Sheu, M. T. (1998). The stability of prostaglandin E1 ethylester. Chinese Pharmaceutical Journal, 50(2), 97-105.

The stability of prostaglandin E1 ethylester. / Lin, Lun Huei; Ho, Hsiu O.; Chen, Kuo Tung; Chiang, Han-Sun; Wong, Patrick Y K; Sheu, Ming Thau.

In: Chinese Pharmaceutical Journal, Vol. 50, No. 2, 04.1998, p. 97-105.

Research output: Contribution to journalArticle

Lin, LH, Ho, HO, Chen, KT, Chiang, H-S, Wong, PYK & Sheu, MT 1998, 'The stability of prostaglandin E1 ethylester', Chinese Pharmaceutical Journal, vol. 50, no. 2, pp. 97-105.
Lin LH, Ho HO, Chen KT, Chiang H-S, Wong PYK, Sheu MT. The stability of prostaglandin E1 ethylester. Chinese Pharmaceutical Journal. 1998 Apr;50(2):97-105.
Lin, Lun Huei ; Ho, Hsiu O. ; Chen, Kuo Tung ; Chiang, Han-Sun ; Wong, Patrick Y K ; Sheu, Ming Thau. / The stability of prostaglandin E1 ethylester. In: Chinese Pharmaceutical Journal. 1998 ; Vol. 50, No. 2. pp. 97-105.
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