The spectrum of T-cell and natural killer/T-cell neoplasms with leukaemic presentation in a single institution in Taiwan

S. T. Chang, Y. C. Hsieh, S. Y. Kuo, C. L. Lu, J. S. Chu, S. S. Chuang

Research output: Contribution to journalArticle

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Abstract

T cell and natural killer (NK)/T-cell neoplasms are rare and may occasionally present as leukaemia. We retrospectively searched T cell and NK/T-cell tumours in a single institution in Taiwan from January 2000 to December 2009 and identified 137 (19.1%) patients with T cell and NK/T-cell tumours among 718 patients with lymphoid neoplasms. Among these 137 patients, 18 (13.1%) presented with leukaemia including T-lymphoblastic lymphoma/leukaemia (T-LBL), T-cell prolymphocytic leukaemia, aggressive NK-cell leukaemia, adult T-cell lymphoma/leukaemia (ATLL), T-cell large granular lymphocytic (T-LGL) leukaemia and unspecified peripheral T-cell lymphoma. Cases with concurrent lymphoma, higher absolute leukaemic cell counts and elevated lactate dehydrogenase level carried a poorer prognosis. The survival was dichotomous, with a very poor prognosis for patients with T-LBL, T-cell prolymphocytic leukaemia, aggressive NK-cell leukaemia, ATLL in acute phase and unspecified peripheral T-cell lymphoma, while those with T-LGL leukaemia and ATLL in chronic phase had a favourable outcome.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalInternational Journal of Laboratory Hematology
Volume34
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Large Granular Lymphocytic Leukemia
Natural Killer T-Cells
T-cells
Taiwan
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Adult T Cell Leukemia Lymphoma
T-Cell Prolymphocytic Leukemia
Peripheral T-Cell Lymphoma
T-Lymphocytes
Neoplasms
Leukemia
L-Lactate Dehydrogenase
Lymphoma
Cell Count
Survival
Tumors

Keywords

  • Large granular lymphocytic leukaemia
  • Peripheral T-cell lymphoma
  • T-cell prolymphocytic leukaemia
  • T-lymphoblastic lymphoma/leukaemia
  • Taiwan

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Hematology

Cite this

The spectrum of T-cell and natural killer/T-cell neoplasms with leukaemic presentation in a single institution in Taiwan. / Chang, S. T.; Hsieh, Y. C.; Kuo, S. Y.; Lu, C. L.; Chu, J. S.; Chuang, S. S.

In: International Journal of Laboratory Hematology, Vol. 34, No. 4, 08.2012, p. 422-426.

Research output: Contribution to journalArticle

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